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AstraZeneca’s Farxiga reduces death risk in heart failure patients

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AstraZeneca’s (AZN.L) blockbuster diabetes drug Farxiga led to significant reductions in the risk of hospitalization and death in people with all types of heart failure, according to study data released on Saturday.

The drug belongs to a class of medicines called SGLT2 inhibitors that were initially approved to treat type 2 diabetes. Since then, the drugs have been shown to benefit patients with chronic kidney and heart disease and prevent heart attacks.

Farxiga is the first heart failure medication to show mortality benefit across all forms of heart failure, the company said as reported by Reuters.

Detailed data from a study called ‘DELIVER’ evaluating Farxiga in patients with a form of heart failure characterized by mildly reduced or preserved ejection fraction was presented at the European Society of Cardiology congress in Barcelona. Ejection fraction measures the heart’s ability to pump oxygen-rich blood into the body.

Farxiga met the study’s primary goal, inducing a statistically significant reduction in the risk of heart-related death, heart failure hospitalization and urgent heart failure visits by 18%.

A pooled analysis of DELIVER and another trial involving about 11,000 heart failure patients combined showed Farxiga reduced the risk of death from cardiovascular causes – including heart attacks – by 14%, and death from any cause by 10%. The drug also cut the risk of hospital admissions for heart failure by close to a third.

Heart failure occurs when the heart muscle becomes unable to pump blood as efficiently as it should, and can cause a range of serious health problems and death. Of the estimated 64 million heart failure patients globally, roughly half have reduced ejection fraction, which is equal to or less than 40%. The remainder have mildly reduced or preserved ejection fraction.

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German medical team launches free surgical mission at Bamiyan provincial hospital

The mission is funded by volunteer doctors and partner organisations, with essential medicines and medical equipment also brought into the country.

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A nine-member medical team from Germany has begun a two-week medical and surgical mission at Bamiyan Provincial Hospital, offering free specialised treatment to patients in need.

According to the Ministry of Public Health, the team arrived in Afghanistan in coordination with the ministry and in partnership with Aga Khan Health Services (AKHS).

During the mission, the specialists will provide diagnostic and surgical services, including plastic surgery, burn treatment, correction of congenital deformities, war-related injuries and other complex medical conditions.

The team is expected to examine around 200 patients, with between 100 and 150 selected for surgical procedures.

In addition to treating patients, the German specialists will conduct theoretical and practical training sessions for Afghan doctors, surgeons and medical students to strengthen local medical expertise.

The ministry said the mission is funded by volunteer doctors and partner organisations, with essential medicines and medical equipment also brought into the country.

The initiative aims to improve access to free specialised healthcare, enhance the skills of Afghan medical professionals and strengthen surgical services in Afghanistan.

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Afghanistan to launch nationwide polio vaccination campaign

UNICEF said that 12.7 million children in Afghanistan have been vaccinated against polio through ongoing immunization campaigns.

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Afghanistan is set to launch a new nationwide polio vaccination campaign on Monday, November 2, as health authorities continue efforts to eradicate the disease, following the vaccination of 12.7 million children across the country.

Afghanistan’s Polio-Free Initiative announced that the campaign will begin nationwide on Monday, while vaccination activities in the southern zone will start a day later, on Tuesday, November 3.

Meanwhile, the United Nations Children’s Fund (UNICEF) said that 12.7 million children in Afghanistan have been vaccinated against polio through ongoing immunization campaigns.

The UN agency noted that despite progress in vaccination coverage, efforts to completely eliminate polio in Afghanistan are continuing.

Polio is a highly infectious viral disease that mainly affects children under the age of five and can cause permanent paralysis.

Health organizations have urged families to cooperate with vaccination teams and ensure that all eligible children receive the required vaccine doses to protect them against the disease.

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Afghanistan urges polio vaccination as cases reach 42

World Polio Day is observed annually on October 24 to raise awareness and strengthen global efforts to eliminate the disease.

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Afghanistan Free Polio has urged parents and caregivers to vaccinate their children against polio, warning of the continued need for vaccination efforts as the country marks World Polio Day on October 24.

In a message issued on Saturday, the organization called on families to ensure their children receive polio vaccines, stressing that every child has the right to grow up free from the disease.

The organization also emphasized the role of families and communities in preventing the spread of the virus and achieving a polio-free Afghanistan.

According to a previous report by the World Health Organization (WHO), six new polio cases had been recorded in Afghanistan, bringing the total number of cases reported since the beginning of 2026 to 42.

Afghanistan and Pakistan remain the only countries where polio has not been eradicated.

World Polio Day is observed annually on October 24 to raise awareness and strengthen global efforts to eliminate the disease.

Health authorities and public health organizations continue to stress that vaccination and community participation are essential to protecting children and preventing further transmission of the virus.

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