The U.S. Department of State has issued an extraordinary directive urging American citizens to immediately depart more than a dozen countries across the Middle East, citing rapidly deteriorating security conditions following joint U.S.-Israeli strikes that killed Iran’s Supreme Leader, Ayatollah Ali Khamenei.

The sweeping advisory comes as retaliatory attacks, embassy closures and major air travel disruptions fuel growing instability across the region.

U.S. officials say the move reflects Washington’s assessment that the crisis could become prolonged and highly volatile, with potential consequences for global security and energy markets.

Broad Regional Advisory

The evacuation notice covers 14 countries and territories, including close U.S. partners such as Israel, Saudi Arabia and the United Arab Emirates. It marks one of the most expansive regional security alerts in recent history.

Officials described “serious safety risks” following coordinated weekend strikes on Iranian targets and subsequent retaliatory operations.

Americans have been urged to leave using commercial flights while they remain available, rather than waiting for potential government-organized evacuations should conditions worsen.

From Targeted Strike to Regional Crisis

The evacuation order follows the killing of Khamenei in coordinated operations that reportedly also targeted other senior Iranian officials. Tehran’s response has included strikes on U.S. and Israeli-linked sites, as well as threats directed at Gulf states and key energy infrastructure.

Concerns have intensified over security in the Strait of Hormuz, a vital shipping route for global oil supplies. Rising tensions in the waterway have already driven up energy prices amid fears of further disruption.

The United States has activated an inter-agency emergency task force to manage the unfolding crisis. President Donald Trump indicated the confrontation could extend beyond a month, underscoring expectations of sustained instability.

International Appeals for Restraint

Global leaders have called for urgent de-escalation. European Commission President Ursula von der Leyen and United Nations Secretary-General António Guterres both urged restraint and renewed diplomatic engagement, warning of severe humanitarian and security consequences.

Russia and China condemned the strike that killed Khamenei as a breach of international law, while France pressed Iran to return to negotiations over its nuclear and ballistic missile programs. The European Union has placed its Red Sea naval mission on heightened alert to safeguard maritime routes amid fears of spillover attacks.

Guidance for U.S. Citizens

Americans in affected countries are advised to contact 24-hour State Department assistance lines and enroll in the Smart Traveler Enrollment Program (STEP) to receive updates. Officials stress the urgency of departing while commercial flights are still operating, as mounting airspace closures and cancellations have already left large numbers of travelers stranded.

Analysts warn that transport disruptions and security risks could persist for days or weeks, urging U.S. citizens to prepare contingency plans in case of extended regional instability.

حامد کرزی، رئیس‌جمهور پیشین افغانستان، و عبدالله عبدالله، رئیس پیشین شورای عالی مصالحه، در واکنش به جان باختن رهبر ایران، آیت‌الله علی خامنه‌ای، ابراز تأسف و همدردی کردند.

بر اساس گزارش‌ها، ایالات متحده و اسرائیل روز شنبه حملات مشترکی را بر چند شهر ایران انجام داده‌اند که به کشته شدن رهبر ایران، و چندین مقام ارشد دیگر منجر شده است.

حامد کرزی در حساب خود در ایکس نوشت: «قدردانی می‌کنم از حمایت مستمر مردم افغانستان از ایشان و همبستگی خود را با مردم شریف ایران اعلام می‌کنم. برای شهدای این حادثه دعا می‌کنم و برای کشور دوست و برادر ایران، صلح، امنیت و پیشرفت آرزو دارم.»

عبدالله عبدالله نیز در صفحه فیسبوک خود نوشت: «با تأثر فراوان، شهادت رهبر ایران، برخی اعضای خانواده و همراهانش، و شهدای اخیر، موجب اندوه عمیق ما گردیده است.»

او دعا کرد تا خداوند به خانواده قربانیان و مردم ایران صبر، بردباری و پاداش عظیم عطا کند.