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No direct evidence COVID started in Wuhan lab: US intelligence report

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U.S. intelligence agencies found no direct evidence that the COVID-19 pandemic stemmed from an incident at China’s Wuhan Institute of Virology, a report declassified on Friday said.

The four-page report by the Office of the Director of National Intelligence (ODNI) said the U.S. intelligence community still could not rule out the possibility that the virus came from a laboratory, however, and had not been able to discover the origins of the pandemic, Reuters reported.

“The Central Intelligence Agency and another agency remain unable to determine the precise origin of the COVID-19 pandemic, as both (natural and lab) hypotheses rely on significant assumptions or face challenges with conflicting reporting,” the ODNI report said.

The report said that while “extensive work” had been conducted on coronaviruses at the Wuhan institute (WIV), the agencies had not found evidence of a specific incident that could have caused the outbreak.

“We continue to have no indication that the WIV’s pre-pandemic research holdings included SARSCoV-2 or a close progenitor, nor any direct evidence that a specific research-related incident occurred involving WIV personnel before the pandemic that could have caused the COVID pandemic,” the report said.

The origins of the coronavirus pandemic have been a matter of furious debate in the United States almost since the first human cases were reported in Wuhan in late 2019.

U.S. President Joe Biden in March signed a bill declassifying information related to the origins of the pandemic.

Biden said at the time of signing that he shared Congress’ goal of releasing as much information as possible about the origin of COVID-19.

The debate was refueled by a Wall Street Journal report in February that the U.S. Energy Department had assessed with “low confidence” in a classified intelligence report that the pandemic most likely arose from a Chinese laboratory leak, an assessment Beijing denies.

FBI director Christopher Wray said on Feb. 28 his agency had assessed for some time that the origins of the pandemic were “most likely a potential lab incident” in the Chinese city of Wuhan. China said this claim had “no credibility whatsoever”.

As of March 20, four other U.S. agencies still judged that COVID-19 was likely the result of natural transmission, while two were undecided.

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Saudi Arabia confirms $500 million pledge to Afghanistan, Pakistan polio campaign

The WHO said the funds, initially pledged in April 2024, will be disbursed to help end the wild form of polio in Pakistan and Afghanistan and stop outbreaks of variant polio.

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The World Health Organization said Monday Saudi Arabia has reaffirmed its $500 million commitment to the Global Polio Eradication Initiative (GPEI).

The WHO said the funds, initially pledged in April 2024, will be disbursed to help end the wild form of polio in Pakistan and Afghanistan and stop outbreaks of variant polio, Reuters reported.

Wild polio — a naturally occurring form of the viral disease — is endemic in Pakistan and Afghanistan, which together reported 99 cases last year, according to the WHO. Variant polio is caused by the weakening of the oral polio vaccine.

The GPEI hopes to declare an end to the wild virus and the vaccine-derived variant by 2027 and 2029, respectively, compared with a previous deadline of 2026 for both forms.

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Chinese researchers find bat virus enters human cells via same pathway as COVID

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A newly discovered bat coronavirus uses the same cell-surface protein to gain entry into human cells as the SARS-CoV-2 virus that causes COVID-19, raising the possibility that it could someday spread to humans, Chinese researchers have reported.

The virus does not enter human cells as readily as SARS-CoV-2 does, the Chinese researchers reported in the journal Cell, opens new tab, noting some of its limitations, Reuters reported.

The scientists said that like SARS-CoV-2, the bat virus HKU5-CoV-2 contains a feature known as the furin cleavage site that helps it to enter cells via the ACE2 receptor protein on cell surfaces.

In lab experiments, HKU5-CoV-2 infected human cells with high ACE2 levels in test tubes and in models of human intestines and airways.

In further experiments, the researchers identified monoclonal antibodies and antiviral drugs that target the bat virus.

Bloomberg, which reported on the study earlier on Friday, said the paper identifying the bat virus had moved shares of COVID vaccine makers. Pfizer shares closed up 1.5% on Friday, Moderna climbed 5.3% and Novavax was up about 1% on a down day for the broader market.

Asked about concerns raised by the report of another pandemic resulting from this new virus, Dr. Michael Osterholm, an infectious disease expert at the University of Minnesota, called the reaction to the study “overblown.”

He said there is a lot of immunity in the population to similar SARS viruses compared with 2019, which may reduce the pandemic risk.

The study itself noted that the virus has significantly less binding affinity to human ACE2 than SARS-CoV-2, and other suboptimal factors for human adaptation suggest the “risk of emergence in human populations should not be exaggerated.”

 

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UN warns maternal deaths in Afghanistan may rise after US funding pause

Afghanistan has one of the highest death rates in the world for pregnant women, with a mother dying of preventable pregnancy complications every two hours

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A United Nations aid official said on Tuesday that Washington’s funding pause would cut off millions of Afghans from sexual and reproductive health services, and that the continued absence of this support could cause over 1,000 maternal deaths in Afghanistan from 2025 to 2028.

US President Donald Trump last month ordered a 90-day pause in foreign development assistance, pending assessment of efficiencies and consistency with his foreign policy, setting alarm bells ringing among aid groups around the world that depend on US funding.

Trump has also restored US participation in international anti-abortion pacts, cutting off US family planning funds for foreign organisations providing or promoting abortion.

Pio Smith, regional director for Asia and the Pacific at the United Nations sexual and reproductive health agency (UNFPA), said that over nine million people in Afghanistan would lose access to services and over 1.2 million Afghan refugees living in Pakistan would also be affected due to the closure of health facilities.

Afghanistan has one of the highest death rates in the world for pregnant women, with a mother dying of preventable pregnancy complications every two hours, he said.

“What happens when our work is not funded? Women give birth alone, in unsanitary conditions…Newborns die from preventable causes,” he told a Geneva press briefing. 

“These are literally the world’s most vulnerable people.”

“If I just take the example of Afghanistan, between 2025 and 2028 we estimate that the absence of US support will result in 1,200 additional maternal deaths and 109,000 additional unintended pregnancies,” he said.

Across the Asia-Pacific region, UNFPA receives about $94 million in US funding, he added.

Riva Eskinazi, director of donor relations at the International Planned Parenthood Federation meanwhile told Reuters it, too, would have to halt family planning and sexual and reproductive health services in West Africa as a result of the pause.

“We can foresee an increase in unintended pregnancies and maternal deaths. There is going to be a problem sending contraceptives to our members. It’s devastating,” she said.

IPPF, a federation of national organisations that advocates for sexual and reproductive health, calculates that it would have to forgo at least $61 million in US funding over four years in 13 countries, most of which are in Africa.

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