Science & Technology
Scientists grow human brain cells in rats to study diseases
Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections.
It’s part of an effort to better study human brain development and diseases affecting this most complex of organs, which makes us who we are but has long been shrouded in mystery.
“Many disorders such as autism and schizophrenia are likely uniquely human” but “the human brain certainly has not been very accessible,” said said Dr. Sergiu Pasca, senior author of a study describing the work, published Wednesday in the journal Nature.
Approaches that don’t involve taking tissue out of the human brain are “promising avenues in trying to tackle these conditions.”
The research builds upon the team’s previous work creating brain “organoids,” tiny structures resembling human organs that have also been made to represent others such as livers, kidneys, prostates, or key parts of them.
To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain’s outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions.
Scientists transplanted those organoids into rat pups 2 to 3 days old, a stage when brain connections are still forming. The organoids grew so that they eventually occupied a third of the hemisphere of the rat’s brain where they were implanted. Neurons from the organoids formed working connections with circuits in the brain.
Human neurons have been transplanted in rodents before, but generally in adult animals, usually mice. Pasca, a psychiatry professor at the Stanford School of Medicine, said this is the first time these organoids have been placed into early rat brains, creating “the most advanced human brain circuitry ever built from human skin cells and a demonstration that implanted human neurons can influence an animal’s behavior.”
To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat’s brain: one generated from a healthy person’s cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder.
Five to six months later, they saw effects of the disease related to the activity of the neurons. There were differences in the two sides’ electrical activity, and the neurons from the person with Timothy syndrome were much smaller and didn’t sprout as many extensions that pick up input from nearby neurons.
Researchers, whose study was funded partly by the National Institutes of Health, said they could do the same sorts of experiments using organoids made from the cells of people with disorders such as autism or schizophrenia — and potentially learn new things about how these conditions affect the brain, too.
Dr. Flora Vaccarino of Yale University – who previously grew lumps containing cerebral cortex that were made with DNA from people with autism – said the study moves the field forward.
Such experiments in animals raise ethical concerns. For example, Pasca said he and his team are cognizant of the rats’ well-being and whether they still behave normally with the organoids inside them, which he says they do. Still, Pasca does not believe this should be tried in primates. Ethicists also wonder about the possibility of brain organoids in the future attaining something like human consciousness, which experts say is extremely unlikely now.
Some scientists are studying human brain organoids outside of animals. For example, researchers at ETH Zurich in Switzerland published a study in Nature earlier this month describing how they are growing brain-like tissue from stem cells in the lab and then mapping the cell types in various brain regions and genes regulating their development. Some are using these structures to study autism.
Science & Technology
Astronomers discover white dwarf surrounded by two rings of planetary debris
Astronomers have discovered a white dwarf star surrounded by two distinct rings of planetary debris, offering new insights into what may happen to planetary systems, including our own, when their host stars reach the end of their lives.
The star, identified as J1328−1450, is located about 1,600 light-years from Earth in the constellation Virgo. Observations made using the European Southern Observatory’s Very Large Telescope in Chile revealed an unusual arrangement of dust and gas around the star.
According to researchers, the debris appears to form two separate rings, a structure not previously observed around any of the 21 white dwarfs known to have surrounding planetary debris.
The scientists believe that two relatively large rocky bodies may have survived the star’s transformation into a white dwarf and could be responsible for shaping the surrounding material. One of these objects may be roughly the size of Pluto, while the other is smaller.
Researchers say the discovery provides further evidence that some rocky planetary bodies can survive the dramatic changes that occur when a star exhausts its fuel and expands into a red giant.
The findings, published in the journal *Nature Astronomy*, suggest that the original star may once have hosted a planetary system. During its expansion, it likely engulfed some of its innermost planets, while more distant objects survived.
Over time, gravitational forces may have pulled some of these surviving bodies closer to the white dwarf, tearing them apart and scattering their material into surrounding rings of dust and gas.
Astronomers also found differences in the chemical composition of the two rings, particularly in their magnesium content, suggesting that they may have originated from different rocky bodies or from different layers of a disrupted object.
The discovery could offer a glimpse into the distant future of our own solar system. Scientists estimate that in about five billion years, the Sun will expand into a red giant before shedding its outer layers and becoming a white dwarf.
During this process, Mercury and Venus are expected to be engulfed, while the fate of Earth remains uncertain. More distant planets, including Jupiter and Saturn, are expected to have a greater chance of surviving.
Researchers say that, after the Sun becomes a white dwarf, surviving planets, moons and asteroids could also be pulled towards it and broken apart by its intense gravitational force.
They suggest that the newly observed system may represent one possible stage in the far-distant future of our solar system.
Science & Technology
Binance says it has covered $6 billion of $6.3 billion stolen in hack
The US Federal Bureau of Investigation (FBI) said on Saturday the North Korean state-sponsored unit known as TraderTraitor was responsible for the attack.
Binance, the world’s biggest cryptocurrency exchange, said it has covered $6 billion of the $6.3 billion stolen from its platform by using company money to buy replacement tokens, after a hack that US officials said was carried out by a North Korean state-sponsored unit known as TraderTraitor.
“We had already covered $6B of the impacted amount of the hacked loss,” Binance said on X on Saturday, after saying earlier that it had covered 90% of the stolen funds, Reuters reported.
The remaining amount, now less than 10%, consists of assets that are less liquid and may take longer to source in the required amounts, according to Binance.
The US Federal Bureau of Investigation (FBI) said on Saturday the North Korean state-sponsored unit known as TraderTraitor was responsible for the attack.
North Korea has for years denied using state-linked cyber units for espionage, financial theft and revenue. Its mission in Geneva and embassy in China did not respond to requests for comment.
Members of the unit were observed by law enforcement converting stolen assets into the cryptocurrency ethereum, the FBI said in a statement, adding that it expects “further laundering” of the assets through the use of related technology.
Analysts had previously blamed North Korea and said it could be the largest financial heist of all time.
Binance has been working with industry partners to freeze some of the affected assets, with about $3 billion located as of Friday.
The company has repeatedly said it would bear the financial impact of the funds stolen in the hack.
The money spent re-buying tokens came from using part of its $1 billion Secure Asset Fund for Users (SAFU), a bitcoin reserve it holds to protect customers in the event of security breaches, as well as some of its Futures Insurance Fund, and the company’s own corporate treasury, it said on X.
Co-CEO Yi He said on Saturday that 50% of its SAFU funds would be used, while the company said it was committing to replenishing the fund to return it to about $1 billion.
Crypto prices fell on Friday, while Binance sought to reassure customers that their funds were safe after the hack.
Co-CEO Richard Teng had said that the breach was a “complex attack” involving a compromised laptop and malicious software designed to delete evidence of its activity, making it harder to trace and investigate.
After the hack, the exchange stopped allowing customers to withdraw their funds, but it said on Saturday it was still on track to reopen withdrawals on Sunday.
Withdrawals were not open as of 02:50 GMT on Sunday.
Binance said it has set aside around $6.34 billion of company funds internally to cover the losses.
Binance also said it had taken a new snapshot of assets held on its platform as of 0000 GMT on October 31, as part of its proof-of-reserves process.
Users holding the 10 listed tokens — BTC, ETH, USDT, BNB, SOL, USDC, XRP, USD1, RLUSD, and ZEC — would be able to verify that their assets were backed at a minimum ratio of 1:1 once the full proof was available, it said.
Science & Technology
Governments take websites offline as critical cyber flaws trigger global alert
Security patches were released prompting authorities to urge organisations to update affected systems immediately or take vulnerable services offline until they could be secured.
Governments and organisations across Europe and beyond have taken websites and online services offline after the discovery of two critical vulnerabilities in widely used web software triggered an international cyber-security alert.
The vulnerabilities affect PHP, a programming language used extensively to operate websites and online applications. Attackers could potentially exploit the flaws to execute malicious code remotely on vulnerable servers, threatening sensitive information and digital infrastructure.
Security patches were released on Wednesday, October 21, prompting authorities to urge organisations to update affected systems immediately or take vulnerable services offline until they could be secured.
The Netherlands, Finland, France, Belgium and Germany have also reported precautionary shutdowns affecting government websites and other public-facing services.
In the Netherlands, affected platforms included Overheid.nl, MijnOverheid.nl and DigiD. The country’s National Cyber Security Centre also temporarily took its own website offline.
Finland’s state IT services provider, Valtori, suspended public government web services as a precaution, while France’s Interior Ministry temporarily took the websites of local administrative authorities offline.
In Belgium, the Foreign Ministry took its websites offline amid concerns about potential exploitation, although the country’s cybersecurity centre said it had not observed attacks on Belgian websites at the time.
Germany’s federal IT service provider also temporarily disabled several websites, with officials saying the measure was precautionary and no security incidents were known to have occurred.
The disruption extended beyond government agencies. Websites and online services belonging to hospitals, educational platforms and other organisations were also affected, highlighting the potential reach of vulnerabilities in widely deployed software.
In Australia, the Australian Cyber Security Centre’s website, cyber.gov.au, was among the government services affected by the security alert. Australian authorities said they were not aware of active exploitation of the vulnerabilities.
In the United States, the National Security Agency and other cybersecurity authorities urged organisations to prepare for immediate updates and take vulnerable systems offline if they could not be secured promptly. The Wikimedia Foundation, which operates Wikipedia, also took some systems offline as a precaution while addressing the flaws.
Cybersecurity company Cloudflare reported seeing early attacks associated with the vulnerabilities, although reports of exploitation do not establish that every affected organisation suffered a breach.
The incident highlights the risks created by the internet’s reliance on shared software. PHP is used across a substantial proportion of websites, meaning a single vulnerability can affect organisations in multiple countries and sectors simultaneously.
Security specialists have urged website operators to identify affected systems, install the relevant patches and examine server logs for signs of unauthorised access. Applying an update may prevent further exploitation, but organisations must also investigate whether attackers gained access before their systems were secured.
Authorities have not established that all affected websites were breached. The precautionary shutdowns are intended to reduce exposure while administrators apply fixes and verify that their systems are safe to restore.
The alert has underscored the challenge facing governments and businesses in responding to critical software vulnerabilities that can rapidly become an international security concern.
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