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Scientists grow human brain cells in rats to study diseases

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Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections.

It’s part of an effort to better study human brain development and diseases affecting this most complex of organs, which makes us who we are but has long been shrouded in mystery.

“Many disorders such as autism and schizophrenia are likely uniquely human” but “the human brain certainly has not been very accessible,” said said Dr. Sergiu Pasca, senior author of a study describing the work, published Wednesday in the journal Nature.

Approaches that don’t involve taking tissue out of the human brain are “promising avenues in trying to tackle these conditions.”

The research builds upon the team’s previous work creating brain “organoids,” tiny structures resembling human organs that have also been made to represent others such as livers, kidneys, prostates, or key parts of them.

To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain’s outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions.

Scientists transplanted those organoids into rat pups 2 to 3 days old, a stage when brain connections are still forming. The organoids grew so that they eventually occupied a third of the hemisphere of the rat’s brain where they were implanted. Neurons from the organoids formed working connections with circuits in the brain.

Human neurons have been transplanted in rodents before, but generally in adult animals, usually mice. Pasca, a psychiatry professor at the Stanford School of Medicine, said this is the first time these organoids have been placed into early rat brains, creating “the most advanced human brain circuitry ever built from human skin cells and a demonstration that implanted human neurons can influence an animal’s behavior.”

To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat’s brain: one generated from a healthy person’s cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder.

Five to six months later, they saw effects of the disease related to the activity of the neurons. There were differences in the two sides’ electrical activity, and the neurons from the person with Timothy syndrome were much smaller and didn’t sprout as many extensions that pick up input from nearby neurons.

Researchers, whose study was funded partly by the National Institutes of Health, said they could do the same sorts of experiments using organoids made from the cells of people with disorders such as autism or schizophrenia — and potentially learn new things about how these conditions affect the brain, too.

Dr. Flora Vaccarino of Yale University – who previously grew lumps containing cerebral cortex that were made with DNA from people with autism – said the study moves the field forward.

Such experiments in animals raise ethical concerns. For example, Pasca said he and his team are cognizant of the rats’ well-being and whether they still behave normally with the organoids inside them, which he says they do. Still, Pasca does not believe this should be tried in primates. Ethicists also wonder about the possibility of brain organoids in the future attaining something like human consciousness, which experts say is extremely unlikely now.

Some scientists are studying human brain organoids outside of animals. For example, researchers at ETH Zurich in Switzerland published a study in Nature earlier this month describing how they are growing brain-like tissue from stem cells in the lab and then mapping the cell types in various brain regions and genes regulating their development. Some are using these structures to study autism.

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Meta turns off Instagram’s private messaging encryption worldwide

Meta said the decision was based on low user adoption, though critics argue optional privacy tools often see limited use because users must manually activate them.

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Instagram has disabled its end-to-end encrypted (E2EE) direct messaging feature worldwide, marking a major reversal by parent company Meta on its previous commitment to stronger user privacy protections.

The move means Instagram users can no longer send ultra-private direct messages protected by E2EE — a security system that allows only the sender and recipient to read messages. Without the feature, Instagram can technically access the content of direct messages, including photos, videos and voice notes.

Meta had previously promoted encryption as “the future is private.” In 2019, CEO Mark Zuckerberg pledged to expand the technology across the company’s platforms.

Facebook Messenger adopted E2EE in 2023, while Instagram introduced it as an optional feature with plans to make it standard.

However, Meta has now abandoned the wider Instagram rollout and updated the app’s terms in March to confirm encrypted messaging would no longer be supported after 8 May 2026.

Meta said the decision was based on low user adoption, though critics argue optional privacy tools often see limited use because users must manually activate them.

The move has divided opinion. Child protection groups, including the NSPCC, welcomed the change, saying encryption can make it harder to detect child grooming and abuse online.

Privacy advocates criticised the decision. Maya Thomas of Big Brother Watch warned the move weakens online privacy protections and could increase pressure on other social media companies to scale back encryption.

End-to-end encryption remains standard on platforms including WhatsApp, Signal, Apple’s iMessage and Google Messages, while other platforms continue to take mixed approaches to private messaging.

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James Webb Telescope captures clearest-ever view of exoplanet’s surface

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Astronomers using NASA’s James Webb Space Telescope have obtained the clearest view yet of the surface of a rocky exoplanet, revealing a scorched, atmosphere-free world that scientists say resembles a giant version of Mercury.

The planet, known as LHS 3844 b and nicknamed “Kua’kua,” appears to be a barren, uninhabitable world with extreme temperature swings and no detectable atmosphere, according to a study published this week in Nature Astronomy.

Researchers said the planet’s surface is likely covered in dark volcanic rock and ancient regolith — loose rocky debris formed over billions of years from relentless bombardment by radiation and micrometeorite impacts.

“This planet is not a nice place,” said astronomer Laura Kreidberg, senior author of the study. “It’s a hellish, barren rock — much more similar to Mercury than Earth.”

Located about 49 light-years away, LHS 3844 b orbits a small red dwarf star and completes a full orbit every 11 hours. The planet is tidally locked, meaning one side permanently faces its star while the other remains in darkness — similar to how the Moon always shows the same face to Earth.

Scientists found the planet’s dayside reaches roughly 1,340 degrees Fahrenheit (725 degrees Celsius), while the nightside showed almost no detectable heat.

Using Webb’s infrared instruments, researchers were able to directly analyze light coming from the planet’s surface — a major breakthrough for exoplanet science.

“Different rocks have different spectral fingerprints,” said lead author Sebastian Zieba. “Dark volcanic rocks like basalt matched our observations much better than brighter rocks like granite.”

The findings mark a new phase in exoplanet research, shifting beyond atmospheric studies toward direct analysis of alien geology and surface composition.

Since becoming operational in 2022, the Webb telescope has transformed scientists’ understanding of planets beyond the solar system, helping identify atmospheric chemistry, weather patterns and now even the nature of distant planetary surfaces.

Researchers said the absence of an atmosphere on LHS 3844 b means there is little protection from stellar radiation and virtually no possibility of liquid water — a key ingredient for life.

“So overall, this is almost certainly not a habitable world,” Zieba said.

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Afghanistan launches first 5G trial in Kabul to boost telecom services

According to ministry spokesperson Enayatullah Alokozai, AWCC has upgraded 74 telecom antennas in Kabul to 5G on a trial basis.

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Afghanistan has launched its first-ever 5G telecommunications trial in Kabul, marking a major milestone in efforts to modernise the country’s digital infrastructure.

The announcement followed a meeting between Hamdullah Nomani, Minister of Communications and Information Technology, and Aliullah Sarwari, head of the Afghan Wireless Communication Company (AWCC), where discussions focused on expanding telecom coverage, improving service quality, and extending connectivity to remote regions.

According to ministry spokesperson Enayatullah Alokozai, AWCC has upgraded 74 telecom antennas in Kabul to 5G on a trial basis. Once technical preparations and testing are completed, the company plans to extend 5G services to other provinces.

Officials also reported steady progress on broader infrastructure development. Eight telecom sites approved during previous official visits to northern and southeastern provinces have been completed, one is nearing completion, and construction continues on two additional sites expected to become operational soon.

In parallel, the Afghanistan Telecom Regulatory Authority (ATRA) has approved eight more telecom sites under the Telecom Development Fund (TDF), with implementation scheduled in the coming months.

Sarwari noted that since the beginning of 2026, AWCC has built and activated 46 telecom sites using its development budget, while work continues on a further 186 sites nationwide.

He also thanked the Ministry of Communications and Information Technology for its ongoing support in facilitating sector growth and improving service delivery.

Nomani meanwhile emphasised that telecommunications play a crucial role in national development and said the government remains committed to working closely with operators to expand modern, high-quality digital services.

Officials added that cooperation between the ministry, regulators, and telecom companies will continue across all operational and regulatory areas to strengthen Afghanistan’s communications network.

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