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US, Hungarian scientists win Nobel Prize for research that led to Covid vaccines

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Scientists Katalin Kariko of Hungary and Drew Weissman of the United States respectively won the 2023 Nobel Prize in Physiology or Medicine for discoveries enabling the development of mRNA Covid-19 vaccines, the award-giving body has announced.

“The 2023 Nobel Prize in Physiology or Medicine has been awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against Covid-19,” the body said on Monday

The prize, among the most prestigious in the scientific world, is selected by the Nobel Assembly of Sweden’s Karolinska Institute Medical University and also comes with 11 million Swedish crowns (about $1 million).

Kariko was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the company. She is also a professor at the University of Szeged in Hungary and adjunct professor at the University of Pennsylvania’s Perelman School of Medicine.

Weissman is professor in vaccine research at the Perelman School.

Kariko found a way to prevent the immune system from launching an inflammatory reaction against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of mRNA.

Together with Weissman, she showed in 2005 that adjustments to nucleosides, the molecular letters that write the mRNA’s genetic code, can keep the mRNA under the immune system’s radar.

‘Major impact on society’

“So this year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system and had a major impact on society during the recent pandemic,” said Rickard Sandberg, member of the Nobel Assembly at Karolinska Institute

The medicine prize kicks off this year’s awards with the remaining five to be unveiled in the coming days.

The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in science, literature and peace, and in later years also for economics.

The Swedish king will present the prizes at a ceremony in Stockholm on Dec. 10, the anniversary of Nobel’s death, followed by a lavish banquet at city hall.

Last year’s medicine prize went to Swede Svante Paabo for sequencing the genome of the Neanderthal, an extinct relative of present-day humans, and for discovering a previously unknown human relative, the Denisovans.

Other past winners include Alexander Fleming, who shared the 1945 prize for the discovery of penicillin, and Karl Landsteiner in 1930 for his discovery of human blood groups.

Health

Respiratory illnesses rise in Gaza with worst to come as winter floods arrive, WHO says

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The World Health Organization warned on Friday of surging respiratory illnesses in Gaza, with worse expected after heavy rains flooded tens of thousands of tents ​housing displaced Palestinians.

“The numbers already show the pressure. Acute respiratory infections are 33,000 ‌cases higher than at the same time last year,” Dr Reinhilde Van De Weerdt, WHO Representative in the Occupied Palestinian Territory, told reporters in Geneva from Jerusalem, Reuters reported.

Poor living conditions and severe overcrowding are driving up ​infections as Gaza’s population is squeezed into an ever-smaller area, WHO said. The crunch ​has worsened as the Israeli military expands its control by advancing the “yellow ⁠line” — a demarcation established under October’s US-brokered ceasefire.

“That means people are living in more crowded ​conditions, where of course the spread between humans of a virus is much more prone ​to spread,” Van De Weerdt explained.

The Israeli military and COGAT, the Israeli military agency that coordinates aid, did not immediately respond to Reuters request for comment.

Last week COGAT said that it had stepped up efforts to ​improve sanitary conditions before the heavy rain, in coordination with international organisations.

Respiratory infections currently make ​up 11% of all consultations, with the WHO expecting cold weather, flooding, overcrowded shelters and poor ventilation ‌to push ⁠these numbers higher.

“It is shocking that just a few days of rain really showed us what the coming months will bring. And winter has not even fully set in. The worst really is yet to come,” Van De Weerdt said.

Nearly a million displaced people in Gaza ​live in flood-exposed areas, ​and 400,000 of ⁠them are in locations that are considered at extremely high risk, according to the WHO.

The agency said flooding heightened the risk of contaminated ​water, while standing water gave mosquitoes and pests more places to breed. ​Dampness encouraged ⁠mould and bacteria that are major drivers for respiratory infections, especially in young children, it said.

While the majority of medicines are getting into Gaza, the WHO faces difficulty getting laboratory supplies, which ⁠it says ​are vital for diagnosing patients before they can be ​treated.

“To prevent outbreaks, we really call to let laboratory equipment enter Gaza today, so that we can avoid a ​public health disaster on top of a disaster.“

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German medical team launches free surgical mission at Bamiyan provincial hospital

The mission is funded by volunteer doctors and partner organisations, with essential medicines and medical equipment also brought into the country.

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A nine-member medical team from Germany has begun a two-week medical and surgical mission at Bamiyan Provincial Hospital, offering free specialised treatment to patients in need.

According to the Ministry of Public Health, the team arrived in Afghanistan in coordination with the ministry and in partnership with Aga Khan Health Services (AKHS).

During the mission, the specialists will provide diagnostic and surgical services, including plastic surgery, burn treatment, correction of congenital deformities, war-related injuries and other complex medical conditions.

The team is expected to examine around 200 patients, with between 100 and 150 selected for surgical procedures.

In addition to treating patients, the German specialists will conduct theoretical and practical training sessions for Afghan doctors, surgeons and medical students to strengthen local medical expertise.

The ministry said the mission is funded by volunteer doctors and partner organisations, with essential medicines and medical equipment also brought into the country.

The initiative aims to improve access to free specialised healthcare, enhance the skills of Afghan medical professionals and strengthen surgical services in Afghanistan.

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Afghanistan to launch nationwide polio vaccination campaign

UNICEF said that 12.7 million children in Afghanistan have been vaccinated against polio through ongoing immunization campaigns.

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Afghanistan is set to launch a new nationwide polio vaccination campaign on Monday, November 2, as health authorities continue efforts to eradicate the disease, following the vaccination of 12.7 million children across the country.

Afghanistan’s Polio-Free Initiative announced that the campaign will begin nationwide on Monday, while vaccination activities in the southern zone will start a day later, on Tuesday, November 3.

Meanwhile, the United Nations Children’s Fund (UNICEF) said that 12.7 million children in Afghanistan have been vaccinated against polio through ongoing immunization campaigns.

The UN agency noted that despite progress in vaccination coverage, efforts to completely eliminate polio in Afghanistan are continuing.

Polio is a highly infectious viral disease that mainly affects children under the age of five and can cause permanent paralysis.

Health organizations have urged families to cooperate with vaccination teams and ensure that all eligible children receive the required vaccine doses to protect them against the disease.

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