Health
US, Hungarian scientists win Nobel Prize for research that led to Covid vaccines
Scientists Katalin Kariko of Hungary and Drew Weissman of the United States respectively won the 2023 Nobel Prize in Physiology or Medicine for discoveries enabling the development of mRNA Covid-19 vaccines, the award-giving body has announced.
“The 2023 Nobel Prize in Physiology or Medicine has been awarded to Katalin Kariko and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against Covid-19,” the body said on Monday
The prize, among the most prestigious in the scientific world, is selected by the Nobel Assembly of Sweden’s Karolinska Institute Medical University and also comes with 11 million Swedish crowns (about $1 million).
Kariko was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the company. She is also a professor at the University of Szeged in Hungary and adjunct professor at the University of Pennsylvania’s Perelman School of Medicine.
Weissman is professor in vaccine research at the Perelman School.
Kariko found a way to prevent the immune system from launching an inflammatory reaction against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of mRNA.
Together with Weissman, she showed in 2005 that adjustments to nucleosides, the molecular letters that write the mRNA’s genetic code, can keep the mRNA under the immune system’s radar.
‘Major impact on society’
“So this year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system and had a major impact on society during the recent pandemic,” said Rickard Sandberg, member of the Nobel Assembly at Karolinska Institute
The medicine prize kicks off this year’s awards with the remaining five to be unveiled in the coming days.
The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in science, literature and peace, and in later years also for economics.
The Swedish king will present the prizes at a ceremony in Stockholm on Dec. 10, the anniversary of Nobel’s death, followed by a lavish banquet at city hall.
Last year’s medicine prize went to Swede Svante Paabo for sequencing the genome of the Neanderthal, an extinct relative of present-day humans, and for discovering a previously unknown human relative, the Denisovans.
Other past winners include Alexander Fleming, who shared the 1945 prize for the discovery of penicillin, and Karl Landsteiner in 1930 for his discovery of human blood groups.
Health
Four-day polio vaccination campaign begins across Afghanistan
A nationwide polio vaccination campaign got underway across Afghanistan on Monday.
The four-day campaign aims to vaccinate around 12.77 million children under the age of five against polio.
Officials said the campaign is aimed at strengthening protection for children against polio and preventing the spread of the virus.
However, in the southern zone of the country, the polio vaccination campaign will begin one day later, on Tuesday, to ensure better implementation.
According to the information provided, Afghanistan has conducted one nationwide and two sub-national polio vaccination campaigns so far this year. The current campaign is the fourth of the year. In addition, localized campaigns and public awareness programs have also been carried out.
Officials said some environmental samples linked to the polio virus have tested positive. However, the Ministry of Public Health has not so far confirmed any human cases of polio.
According to officials, investigations into suspected cases are ongoing, and information on confirmed human cases will be shared once the assessments are completed and sufficient evidence is available.
Health
Afghanistan faces cancer treatment crisis
Spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country.
The Afghanistan Cancer Foundation has raised concern over the rising number of cancer cases across the country, saying at least 1.5 million people are currently suffering from the disease.
According to figures released on Saturday, September 11, about 50,000 new cases are recorded annually. The figures are based on data from the Ministry of Public Health and international organizations.
Shafiq Shinwari, head of the Afghan Cancer Foundation, said in a recent interview that breast and uterine cancers are among the most common cancers in women, while lung, stomach, prostate and colon cancers are widespread among men.
He said cancer is the second-leading cause of death in Afghanistan after heart disease.
Cancer specialist Dr. Rahim Gul Darwish identified smoking and tobacco use, poor hygiene and unhealthy diets as major factors contributing to the spread of the disease.
Meanwhile, Sharafat Zaman Amarkhail, spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country. However, he acknowledged serious shortages of modern equipment and facilities needed to provide comprehensive treatment.
The situation has been further aggravated by the departure of hundreds of medical specialists and healthcare workers since the Islamic Emirate returned to power, according to reports.
Afghan patients have also faced growing difficulties accessing treatment abroad. Many previously travelled to Pakistan for cancer care, but border closures and restrictions on Pakistani visas have made access more difficult.
Doctors say cancer patients require continuous treatment and regular specialist care, warning that shortages of facilities and restrictions on cross-border travel are increasing the risks for patients.
Health
Genetically modified pig kidney keeps man alive for record nine months
A genetically modified pig kidney has kept a 66-year-old man with end-stage kidney disease alive without dialysis for a record nine months, marking the first time a pig kidney has successfully served as a temporary “bridge” to a human kidney transplant.
Tim Andrews, from New Hampshire, was suffering from severe kidney failure caused by type 2 diabetes. Doctors said he had only a 9% chance of receiving a human kidney within five years, while facing a more than 40% risk of dying or being removed from the transplant waiting list.
Surgeons at Mass General Brigham in Massachusetts transplanted a kidney from a genetically modified Yucatan miniature pig named Wilma into Andrews in January 2025. The kidney functioned for 271 days, allowing him to remain free of dialysis before it began to fail.
After the pig kidney was removed, Andrews spent several months back on dialysis before receiving a kidney from a deceased human donor. The human kidney was functioning well after six months of follow-up, according to findings published in the medical journal The Lancet.
The transplant represents the longest dialysis-free survival recorded following a pig kidney xenotransplant in a living person. It is also the first documented case in which a patient successfully moved from a pig kidney transplant to a human kidney transplant.
Before the procedure, Wilma’s genome underwent 69 genetic modifications. Some changes were intended to reduce the risk of viruses being transmitted to humans, while others were designed to make the pig kidney more compatible with the human immune system and reduce the risk of rejection.
Andrews described the procedure as a “miracle”, saying it allowed him to return to everyday activities. He said he was able to cook, vacuum and take long walks with his dog.
The development could offer a potential solution to the severe shortage of human organs available for transplantation. Kidney transplantation provides the best survival prospects and quality of life for patients with end-stage kidney disease, but the global demand for donor kidneys far exceeds the supply.
Dr Leonardo Riella of Mass General Brigham said the shortage of organs remains “the greatest crisis” in transplantation. He said genetically modified animal organs could initially be used to help patients avoid dialysis while they wait for a human donor kidney and could eventually become a long-term treatment option if their safety and durability are established.
The pig kidney began showing damage to its blood vessels after about six months, eventually leading to organ failure and its removal nine months after transplantation.
Doctors found no new antibodies against human tissue following the procedure, suggesting the pig kidney did not make Andrews’ subsequent human transplant more difficult. No pig viruses or other pig pathogens were detected at any point.
The researchers cautioned that the result is based on a single patient with no comparison group. They said the outcome also depended on careful patient selection and intensive specialist care that may not be available in all settings.
Further clinical trials will be needed to determine whether genetically modified pig kidneys can safely and reliably be used as a bridge for other patients facing long waits for human organs.
The researchers said the case nevertheless provides new evidence that pig kidney transplantation could help address the global organ shortage and potentially offer patients a way to remain off dialysis while waiting for a human kidney.
-
Latest News5 days agoAriana Afghan Airlines ranks seventh among 45 Central Asian airlines
-
Regional4 days agoIran airlines cancel flights as US sanctions hit
-
Latest News5 days agoSilk Road highway in Wakhan corridor now reaches the China border
-
Sport4 days agoAfghanistan open Asian Games cricket campaign with win over Japan
-
World4 days agoTrump welcomes Chinese President Xi as US-China summit gets underway
-
Latest News5 days agoOIC Contact Group reaffirms support for Afghan people
-
Latest News5 days agoRefugees minister, UNAMA deputy discuss challenges facing returnees
-
Latest News4 days agoKhalilzad warns Pakistan-Afghanistan tensions likely to worsen after fresh airstrikes

