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Mpox virus detected in Pakistan, health authorities say

Earlier on Friday, the health department in northern Khyber Pakhtunkhwa province said three cases had been detected in patients on arrival from the United Arab Emirates. It was not clear whether the patient confirmed by the central health ministry was among the three.

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Pakistan’s health ministry has confirmed at least one case of the mpox virus in a patient who had returned from a Gulf country, it said on Friday, as provincial health authorities reported they had detected at least three cases.

A health ministry spokesperson said the sequencing of the confirmed case was underway, and that it would not be clear which variant of mpox the patient had until the process was complete, Reuters reported.

A new form of the virus has triggered global concern because it seems to spread more easily though routine close contact. A case of the new variant was confirmed on Thursday in Sweden and linked to a growing outbreak in Africa, the first sign of its spread outside the continent.

However, the World Health Organization has advised against any travel restrictions to stop the spread of mpox.

Earlier on Friday, the health department in northern Khyber Pakhtunkhwa province said three cases had been detected in patients on arrival from the United Arab Emirates. It was not clear whether the patient confirmed by the central health ministry was among the three.

A health officer in Khyber Pakhtunkhwa’s Mardan district said separately the location of a confirmed mpox patient, a man who had recently returned from Saudi Arabia, was unknown.

He had initially received tests and advice at a hospital in the provincial capital Peshawar, Dr Javed Iqbal told Reuters, but later returned to his home a few hours away in Mardan and then went to another district.

“When we visited his home in Mardan, it was locked from outside and his neighbours told us that the family has left for Dir,” said the DHO Mardan.

“We approached our fellow colleagues of the health department in Dir district, but they couldn’t trace him even in Dir.”

The national health ministry said it was carrying out contact tracing of the patient it had identified, who they said was from Mardan. They were also boosting airport surveillance and monitoring with extra health personnel, the ministry said in a statement.

The WHO declared the recent outbreak of the disease as a public health emergency of international concern after the new variant of the virus was identified.

Health ministry spokesman Sajid Shah said so far they had no confirmation of the new variant, but the sequencing of the sample of the confirmed patient was underway.

“Once that’s done, we will be able to say what strain is this,” said Shah.

Salim Khan, the director general of health services for Khyber Pakhtunkhwa, said three patients were in quarantine.

Global health officials on Thursday confirmed an infection with a new strain of the mpox virus in Sweden and linked it to a growing outbreak in Africa, the first sign of its spread outside the continent.

The WHO on Wednesday sounded its highest level of alert over the outbreak in Africa after cases in the Democratic Republic of Congo spread to nearby countries.

There have been 27,000 cases and more than 1,100 deaths, mainly among children, in Congo since the current outbreak began in January 2023.

The disease, caused by the monkeypox virus, leads to flu-like symptoms and pus-filled lesions. It is usually mild but can kill, with children, pregnant women and people with weakened immune systems, such as those with HIV, all at higher risk of complications.

Health

Four-day polio vaccination campaign begins across Afghanistan

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A nationwide polio vaccination campaign got underway across Afghanistan on Monday.

The four-day campaign aims to vaccinate around 12.77 million children under the age of five against polio.

Officials said the campaign is aimed at strengthening protection for children against polio and preventing the spread of the virus.

However, in the southern zone of the country, the polio vaccination campaign will begin one day later, on Tuesday, to ensure better implementation.

According to the information provided, Afghanistan has conducted one nationwide and two sub-national polio vaccination campaigns so far this year. The current campaign is the fourth of the year. In addition, localized campaigns and public awareness programs have also been carried out.

Officials said some environmental samples linked to the polio virus have tested positive. However, the Ministry of Public Health has not so far confirmed any human cases of polio.

According to officials, investigations into suspected cases are ongoing, and information on confirmed human cases will be shared once the assessments are completed and sufficient evidence is available.

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Health

Afghanistan faces cancer treatment crisis

Spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country.

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The Afghanistan Cancer Foundation has raised concern over the rising number of cancer cases across the country, saying at least 1.5 million people are currently suffering from the disease.

According to figures released on Saturday, September 11, about 50,000 new cases are recorded annually. The figures are based on data from the Ministry of Public Health and international organizations.

Shafiq Shinwari, head of the Afghan Cancer Foundation, said in a recent interview that breast and uterine cancers are among the most common cancers in women, while lung, stomach, prostate and colon cancers are widespread among men.

He said cancer is the second-leading cause of death in Afghanistan after heart disease.

Cancer specialist Dr. Rahim Gul Darwish identified smoking and tobacco use, poor hygiene and unhealthy diets as major factors contributing to the spread of the disease.

Meanwhile, Sharafat Zaman Amarkhail, spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country. However, he acknowledged serious shortages of modern equipment and facilities needed to provide comprehensive treatment.

The situation has been further aggravated by the departure of hundreds of medical specialists and healthcare workers since the Islamic Emirate returned to power, according to reports.

Afghan patients have also faced growing difficulties accessing treatment abroad. Many previously travelled to Pakistan for cancer care, but border closures and restrictions on Pakistani visas have made access more difficult.

Doctors say cancer patients require continuous treatment and regular specialist care, warning that shortages of facilities and restrictions on cross-border travel are increasing the risks for patients.

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Genetically modified pig kidney keeps man alive for record nine months

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A genetically modified pig kidney has kept a 66-year-old man with end-stage kidney disease alive without dialysis for a record nine months, marking the first time a pig kidney has successfully served as a temporary “bridge” to a human kidney transplant.

Tim Andrews, from New Hampshire, was suffering from severe kidney failure caused by type 2 diabetes. Doctors said he had only a 9% chance of receiving a human kidney within five years, while facing a more than 40% risk of dying or being removed from the transplant waiting list.

Tim Andrews preparing for surgery in January 2025

Surgeons at Mass General Brigham in Massachusetts transplanted a kidney from a genetically modified Yucatan miniature pig named Wilma into Andrews in January 2025. The kidney functioned for 271 days, allowing him to remain free of dialysis before it began to fail.

After the pig kidney was removed, Andrews spent several months back on dialysis before receiving a kidney from a deceased human donor. The human kidney was functioning well after six months of follow-up, according to findings published in the medical journal The Lancet.

The transplant represents the longest dialysis-free survival recorded following a pig kidney xenotransplant in a living person. It is also the first documented case in which a patient successfully moved from a pig kidney transplant to a human kidney transplant.

Before the procedure, Wilma’s genome underwent 69 genetic modifications. Some changes were intended to reduce the risk of viruses being transmitted to humans, while others were designed to make the pig kidney more compatible with the human immune system and reduce the risk of rejection.

Andrews described the procedure as a “miracle”, saying it allowed him to return to everyday activities. He said he was able to cook, vacuum and take long walks with his dog.

The development could offer a potential solution to the severe shortage of human organs available for transplantation. Kidney transplantation provides the best survival prospects and quality of life for patients with end-stage kidney disease, but the global demand for donor kidneys far exceeds the supply.

Dr Leonardo Riella of Mass General Brigham said the shortage of organs remains “the greatest crisis” in transplantation. He said genetically modified animal organs could initially be used to help patients avoid dialysis while they wait for a human donor kidney and could eventually become a long-term treatment option if their safety and durability are established.

The pig kidney began showing damage to its blood vessels after about six months, eventually leading to organ failure and its removal nine months after transplantation.

Doctors found no new antibodies against human tissue following the procedure, suggesting the pig kidney did not make Andrews’ subsequent human transplant more difficult. No pig viruses or other pig pathogens were detected at any point.

The researchers cautioned that the result is based on a single patient with no comparison group. They said the outcome also depended on careful patient selection and intensive specialist care that may not be available in all settings.

Further clinical trials will be needed to determine whether genetically modified pig kidneys can safely and reliably be used as a bridge for other patients facing long waits for human organs.

The researchers said the case nevertheless provides new evidence that pig kidney transplantation could help address the global organ shortage and potentially offer patients a way to remain off dialysis while waiting for a human kidney.

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