Science & Technology
N.Korea fires salvo of missiles, including ICBM, hours after Biden leaves Asia
North Korea fired three missiles, including one thought to be an intercontinental ballistic missile (ICBM) on Wednesday, after U.S. President Joe Biden left Asia following a trip in which he agreed to new measures to deter the nuclear-armed state.
South Korea’s Joint Chiefs of Staff (JCS) said the three missiles were fired in less than an hour from the Sunan area of the North’s capital, Pyongyang, where its international airport has become a hub of missile tests.
The first missile launched on Wednesday appeared to be an ICBM, while a second unidentified missile appears to have failed mid-flight, the JCS said. The third missile was a short-range ballistic missile (SRBM), it said.
In response, the United States and South Korea held combined live-fire drills, including surface-to-surface missile tests involving the Army Tactical Missile System (ATACMS) of the U.S. and the South’s Hyunmoo-2 SRBM, both militaries said.
“Our military’s show of force was intended to highlight our resolve to firmly respond to any North Korean provocations, including an ICBM launch, and our overwhelming capability and readiness to conduct a surgical strike on the origin of the provocation,” the JCS said in a statement.
North Korea has conducted a flurry of missile launches this year, from hypersonic weapons to test firing its largest ICBMs for the first time in nearly five years. It also appears to be preparing for what would be its first nuclear test since 2017.
U.S. and South Korean officials had recently warned that North Korea appeared ready for another weapons test, possibly during Biden’s visit, which was his first trip to Asia as president and included a summit with South Korean President Yoon Suk-yeol in Seoul.
Yoon, who took office on May 10, convened his first meeting of the national security council, which strongly condemned the latest launch as a “grave provocation”, especially as it came before Biden returned home.
Yoon ordered the aides to strengthen the U.S. extended deterrence and combined defence posture as agreed with Biden, his office said.
“North Korea’s continued provocations will only result in even stronger, faster South Korea-U.S. deterrence, and bring deeper isolation upon itself,” Yoon’s government said in a separate statement.
A White House official said that Biden, who departed Japan on Tuesday evening, had been briefed on the launches and would continue to receive updates.
South Korean Foreign Minister Park Jin and U.S. Secretary of State Antony Blinken also agreed to step up diplomatic efforts to reinforce extended deterrence and facilitate a new U.N. sanctions resolution in a phone call, Seoul’s ministry said.
“We call on the DPRK to refrain from further provocations and engage in sustained and substantive dialogue,” a State Department spokesperson said, using the initials of North Korea’s official name.
SHOW OF FORCE
Pyongyang resumed ICBM testing in late March, ending its self-imposed 2017 moratorium on long-range missile and nuclear testing, amid stalled denuclearisation talks with Washington.
In Wednesday’s test, the suspected ICBM flew 360 km (223.7 miles) to a maximum altitude of 540 km, while the SRBM flew 760 km to a maximum altitude of 60 km, the JCS said.
Japan reported at least two launches, one of which flew about 300 km and reached a maximum altitude of 550 km, and the other to the distance of about 750 km (465 miles) and a maximum altitude of 50 km, Japan’s defence minister said.
Japanese broadcaster NHK said the missiles appeared to have fallen outside Japan’s exclusive economic zone (EEZ).
Japanese chief cabinet secretary Hirokazu Matsuno said the North could take more provocative actions, including a nuclear test.
The U.S. military’s Indo-Pacific Command said it was aware of “multiple” launches. They highlighted the “destabilising impact of the DPRK’s illicit weapons programme” but did not pose an immediate threat.
In Seoul over the weekend, Biden and Yoon agreed to hold bigger military drills and deploy more U.S. strategic assets if necessary to deter North Korea’s intensifying weapons tests.
But they also offered to send COVID-19 vaccines to North Korea as the isolated country battles its first confirmed outbreak, and called on Pyongyang to return to diplomacy.
There had been no response from Pyongyang to the diplomatic overtures or offers of aid, Biden said at the time.
The waning hours of Biden’s visit to the region also saw Russian and Chinese bombers flying joint patrols near Japanese and South Korea air defence zones on Tuesday in a pointed farewell.
Science & Technology
UAE sets minimum social media age at 15, mandates age checks
The government said the measures were designed to address concerns over children’s exposure to inappropriate content, unsafe online interactions, excessive social media use and the collection of personal data.
The United Arab Emirates has set a minimum age of 15 for social media use, becoming the first Arab country to introduce such a restriction as governments worldwide seek to address growing concerns over the impact of online platforms on children.
Under a resolution approved on Thursday, children under 15 will be prohibited from creating, using or operating personal social media accounts. The ban means they will not be able to post content, comment, share or join public groups, the government’s media office said, Reuters reported.
Teenagers aged 15 and 16 will be allowed to use social media platforms subject to enhanced safeguards, including age-appropriate content controls, restrictions on interaction with unknown users, screen-time management tools and parental supervision features.
The rules apply to all social media platforms operating in the UAE and require companies to implement robust age-verification measures, including digital identity checks and artificial intelligence-supported technologies. Self-declaration of age will not be accepted as a valid form of verification.
Platforms must also disable accounts created by children under 15, prevent users from circumventing age-verification systems and refrain from using children’s personal data for targeted advertising or behavioural profiling.
The government said the measures were designed to address concerns over children’s exposure to inappropriate content, unsafe online interactions, excessive social media use and the collection of personal data.
Social media companies will have up to 12 months to comply with the new regulations.
The UAE said the framework aligns with international efforts to strengthen online child protection while balancing digital access with safety.
Several countries, including Australia and others in Europe, have moved to tighten restrictions on children’s use of social media amid mounting concerns about its effects on mental health and online safety.
Regional
Iran banks hit by major cyber attack
Officials said a technical investigation confirmed that the disruptions were the result of a cyberattack.
Several major Iranian banks experienced service disruptions on Saturday following a cyberattack, according to the Coordinating Committee of Iran’s state-owned banks.
The outage affected four major financial institutions, including Bank Melli Iran, Bank Saderat Iran, and Bank Tejarat, causing interruptions to mobile and online banking services, automated teller machines (ATMs), point-of-sale (POS) terminals, and some card transactions.
Officials said a technical investigation confirmed that the disruptions were the result of a cyberattack.
The affected banks stated that their technical teams immediately implemented precautionary measures after detecting the incident in an effort to safeguard customer information and protect banking infrastructure.
Qatasi, secretary of the Coordinating Committee of Iran’s state-owned banks, said necessary recovery and repair measures had been carried out.
Authorities said there is currently no evidence that customer data was accessed without authorization, and no data breach has been reported.
Science & Technology
GLP-1 drugs may have a beneficial effect across many types of cancer
The drugs, originally designed to treat diabetes and found to promote weight loss, have also shown benefits for heart risks, sleep apnea and alcohol and substance abuse.
A growing body of evidence suggests that popular GLP-1 drugs, widely used for weight loss and diabetes, can provide protection against many types of cancer, Reuters reported.
More than two dozen studies presented over the past few days at the American Society of Clinical Oncology meeting in Chicago found that patients taking the drugs showed lower risks of developing cancer and disease progression, better survival, and improved responses to some treatments, compared with people who were not taking the GLP-1s.
The studies included analyses of clinical records and real-world databases tracking patients taking Novo Nordisk’s (NOVOb.CO), Wegovy or Ozempic, Eli Lilly’s (LLY.N), Zepbound or Mounjaro, or older GLP-1 treatments.
The studies were not designed to show how or why GLP-1 use might affect cancer treatment. But researchers believe by reducing inflammation, regulating insulin signaling and possibly engaging directly with tumor biology, they may contribute to a protective effect in cancer patients.
“Chronic inflammation is a fundamental biological pathway involved in the development and progression of many cancers,” said Dr. Elizabeth Susan McDonald of the University of Pennsylvania.
McDonald on Tuesday reported on a study of 110,000 women, showing those who took GLP-1 medications were up to 35% less likely to develop breast cancer than those who did not.
While obesity itself is a known risk factor for certain cancers, the anti-inflammatory effects of GLP-1s will likely prove to have a role in cancer prevention, McDonald said.
GLP-1 drugs include semaglutide, the active ingredient in Wegovy, Ozempic and Rybelsus; tirzepatide, sold as Mounjaro and Zepbound, as well as Lilly’s Trulicity, or dulaglutide, and Novo’s older liraglutide, sold as Saxenda and Victoza.
Some of the strongest signals of benefit came from a study of more than 12,000 patients that showed GLP-1 use was associated with markedly lower odds of cancers advancing to metastatic disease, particularly in lung, breast, colorectal and liver cancers.
People with those cancers who took liraglutide, pramlintide, dulaglutide, tirzepatide, lixisenatide, or semaglutide were 38% to 50% less likely to see the disease spread than people who took drugs from a different class of diabetes medicines known as gliptins.
Reduced cancer incidence, longer survival, and fewer metastases were also seen with GLP-1 use in patients with endometrial, bladder and prostate cancers, as well as in those with small intestine neoplasms and blood cancers, multiple studies found.
A separate analysis of patients treated at U.S. community oncology practices found GLP-1 use was associated with significantly better overall survival across six tumor types – breast, prostate, colorectal, lung, liver and kidney – with a roughly one-third reduction in the risk of death.
Researchers also reported that cancer patients receiving immunotherapies such as Merck’s (MRK.N), Keytruda and Bristol Myers Squibb’s (BMY.N), Opdivo or Yervoy appeared to fare better when they were taking GLP-1 drugs, suggesting a possible interaction with the immune system.
GLP-1 users with type 2 diabetes and stage 3 kidney disease had substantially lower mortality and lower rates of several malignancies, particularly lung, colorectal, and hepatocellular cancers, than non-users, read the report.
While GLP-1 medications carry a warning regarding a possible association with a type of thyroid cancer based on rodent studies, researchers say the recent findings point to a potential beneficial class effect across tumor types, rather than benefits confined to a small subset of cancers.
The drugs, originally designed to treat diabetes and found to promote weight loss, have also shown benefits for heart risks, sleep apnea and alcohol and substance abuse.
“These drugs have never been just glucose-lowering agents,” Dr. Marcin Chwistek of the Fox Chase Cancer Center in Philadelphia said at an ASCO press briefing.
Researchers cautioned that nearly all of the data presented were from observational studies, raising the risk of confounding factors. Patients prescribed GLP-1 drugs may differ in important ways, including overall health, access to care and concurrent treatments, that could influence outcomes.
While the various studies tried to account for those differences, none can prove the drugs improve cancer outcomes. Experts said trials in which GLP-1s are added to standard treatment in some cancer patients but not others are needed to establish clear anti-cancer benefits. Some trials are already being planned.
The apparent cancer benefits were not clearly tied to the drugs’ weight-loss effects, suggesting that alone does not explain the findings, Reuters reported.
A seven-year study with nearly 120,000 participants found GLP-1s were associated with lower rates of new prostate cancer diagnoses in high-risk men, compared to drugs such as Merck’s Propecia and GSK’s (GSK.L), Avodart, which are used to shrink enlarged prostate glands.
GLP-1 users had a “very small” reduction in body weight at one year, said Dr. Colton Jones of the University of Texas San Antonio Mays Cancer Center who presented the study at ASCO.
“We hypothesize that both weight loss and a direct anti-cancer effect and anti-inflammatory effect may be driving the associations observed in our study,” Jones said.
ASCO expert Chwistek said anti-inflammatory and immune-modulating properties have long suggested broader effects of GLP-1s.
Referring to one of the largest studies, Chwistek said: “What’s new here is the consistency across tumor types, and data this large and this consistent warrant a prospective randomized trial.”
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