Health
Experts warn bird flu virus changing rapidly in largest ever outbreak

The virus causing record cases of avian influenza in birds across the world is changing rapidly, experts have warned, as calls increase for countries to vaccinate their poultry.
While emphasizing that the risk to humans remains low, the experts who spoke to AFP said that the surging number of bird flu cases in mammals was a cause for concern.
Since first emerging in 1996, the H5N1 avian influenza virus had previously been confined to mostly seasonal outbreaks.
But “something happened” in mid-2021 that made the group of viruses much more infectious, according to Richard Webby, the head of a World Health Organization collaborating center studying influenza in animals.
Since then, outbreaks have lasted all year round, spreading to new areas and leading to mass deaths among wild birds and tens of millions of poultry being culled, AFP reported.
Webby, who is a researcher at St Jude Children’s Research Hospital in the US city of Memphis, told AFP it was “absolutely” the largest outbreak of avian influenza the world had seen.
He led research, published this week in the journal Nature Communications, showing how the virus rapidly evolved as it spread from Europe into North America.
The study said the virus increased in virulence, which means it causes more dangerous disease, when it arrived in North America.
The researchers also infected a ferret with one of the new strains of bird flu.
They found an unexpectedly “huge” amount of the virus in its brain, Webby said, indicating it had caused more serious disease than previous strains.
Emphasizing that the risk in humans was still low, he said that “this virus is not being static, it’s changing”.
“That does increase the potential that even just by chance” the virus could “pick up genetic traits that allow it to be more of a human virus,” he said.
In rare cases, humans have contracted the sometimes deadly virus, usually after coming in close contact with infected birds.
The virus has also been detected in a soaring number of mammals, which Webby described as a “really, really troubling sign”.
Last week Chile said that nearly 9,000 sea lions, penguins, otters, porpoises and dolphins have died from bird flu along its north coast since the start of the year, AFP reported.
Most mammals are believed to have contracted the virus by eating an infected bird.
But Webby said that what “scares us the most” are indications from a Spanish mink farm, or among sea lions off South America, that the virus could be transmitting between mammals.
Ian Brown, virology head at the UK’s Animal and Plant Health Agency, said there has not yet been “clear evidence that this virus is easily sustaining in mammals.”
While the virus is changing to become “more efficient and more effective in birds,” it remains “unadapted to humans,” Brown told AFP.
Avian viruses bind to different receptors on the host cell than human viruses, Webby said.
It would take “two or three minor changes in one protein of the viruses” to become more adapted to humans, he said.
“That is what we’re really looking out for.”
Vaccinating poultry
One way to bring down the number of total bird flu cases, and therefore reduce the risk to humans, would be for countries to vaccinate their poultry, Webby said.
A few nations including China, Egypt and Vietnam have already held vaccination campaigns for poultry.
But many other countries have been reluctant due to import restrictions in some areas, and fears vaccinated birds that nonetheless get infected could slip through the net.
In April, the United States started testing several vaccine candidates for potential use on birds.
France recently said it hopes to start vaccinating poultry as early as autumn this year.
Christine Middlemiss, the UK’s chief veterinary officer, said that vaccinating poultry was not “a silver bullet because the virus changes constantly”.
But traditionally reluctant countries should consider vaccinating poultry more often, Middlemiss told AFP at an event at the UK’s embassy in Paris last week.
World Organisation for Animal Health director general Monique Eloit said that the issue of vaccinating poultry should be “on the table”.
After all, “everyone now knows that a pandemic is not just a fantasy — it could be a reality,” she added.
Health
Nationwide polio vaccination campaign kicks off, target is 11 million children

The Ministry of Public Health of Afghanistan says that the Ministry in cooperation with the relevant United Nations agencies started a nationwide polio vaccination campaign on Monday.
According to the ministry, the aim of the campaign is to vaccinate more than 11 million children under the age of five against the wild polio virus.
The ministry added that vitamin A capsules are also given to children who are between the ages of 5 and 6.
“Unfortunately, 5 positive cases of polio have been recorded in 2023, which is very worrying for us,” read the ministry’s statement.
“We are committed to eradicating polio in Afghanistan with the cooperation of our partners. The recent positive cases of polio are worrying and we will continue polio vaccination campaigns and basic health services until the complete eradication of this disease,” said Dr. Qalandar Ebaad, Minister of Public Health.
Ebaad further added: “The support of all Afghans, especially the elders of the areas and religious scholars is important in the eradication of polio. They need to participate in the fight against polio.”
Polio is a highly infectious disease caused by a virus. It invades the nervous system and can cause total paralysis in a matter of hours.
The virus is transmitted by person-to-person. Initial symptoms are fever, fatigue, headache, vomiting, stiffness of the neck and pain in the limbs. One in 200 infections leads to irreversible paralysis (usually in the legs). Among those paralyzed, 5–10% die when their breathing muscles become immobilized.
Polio mainly affects children under 5 years of age. However, anyone of any age who is unvaccinated can contract the disease.
There is no cure for polio, it can only be prevented.
Health
Health minister unveils new emergency call center

The Islamic Emirate of Afghanistan’s (IEA) public health minister, Dr Qalandar Ibaad, has officially launched the newly established call center for emergencies.
The National Emergency Operations Center, will be run by Dr Nek Wali Shah Momin, and will respond to medical-related questions and concerns of the public.
“This is the responsibility of the Call Center to promptly respond to the questions and concerns of the people in close coordination with the relevant departments,” added the minister before cutting the ribbon.
The Call Center is technically and financially supported by UNICEF and is also focused on polio eradication.
It is equipped with state-of-the-art technology and staffed by highly trained call agents. This new facility will provide assistance to citizens, ensuring swift resolution of their queries and concerns.
This center will also drive awareness and communicate through telephonic conversations, messages and surveys.
Health
Pig heart transplanted into human patient for the second time

Surgeons have transplanted a pig’s heart into a dying man in a bid to prolong his life – only the second patient to ever undergo such an experimental feat. Two days later, the man was cracking jokes and able to sit in a chair, Maryland doctors said Friday.
The 58-year-old Navy veteran was facing near-certain death from heart failure but other health problems meant he wasn’t eligible for a traditional heart transplant, according to doctors at University of Maryland Medicine, the Associated Press reported.
“Nobody knows from this point forward. At least now I have hope and I have a chance,” Lawrence Faucette, from Frederick, Maryland, said in a video recorded by the hospital before Wednesday’s operation. “I will fight tooth and nail for every breath I can take.”
While the next few weeks will be critical, doctors were thrilled at Faucette’s early response to the pig organ.
“You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The Associated Press. He said doctors are feeling “a great privilege but, you know, a lot of pressure.”
The same Maryland team last year performed the world’s first transplanet of a genetically modified pig heart into another dying man, David Bennett, who survived just two months.
There’s a huge shortage of human organs donated for transplant. Last year, there were just over 4,100 heart transplants in the U.S., a record number but the supply is so tight that only patients with the best chance of long-term survival get offered one.
Attempts at animal-to-human organ transplants have failed for decades, as people’s immune systems immediately destroyed the foreign tissue. Now scientists are trying again using pigs genetically modified to make their organs more humanlike.
Recently, scientists at other hospitals have tested pig kidneys and hearts in donated human bodies, hoping to learn enough to begin formal studies of what are called xenotransplants.
To make this new attempt in a living patient outside of a rigorous trial, the Maryland researchers required special permission from the Food and Drug Administration, under a process reserved for certain emergency cases with no other options.
It took over 300 pages of documents filed with FDA, but the Maryland researchers made their case that they’d learned enough from their first attempt last year – even though that patient died for reasons that aren’t fully understood – that it made sense to try again.
And Faucette, who retired as a lab technician at the National Institutes of Health, had to agree that he understood the procedure’s risks.
In a statement his wife, Ann Faucette, said: “We have no expectations other than hoping for more time together. That could be as simple as sitting on the front porch and having coffee together.”
What’s different this time: Only after last year’s transplant did scientists discover signs of a pig virus lurking inside the heart – and they now have better tests to look for hidden viruses. They also made some medication changes.
Possibly more important, while Faucette has end-stage heart failure and was out of other options, he wasn’t as near death as the prior patient.
By Friday, his new heart was functioning well without any supportive machinery, the hospital said.
“It’s just an amazing feeling to see this pig heart work in a human,” said Dr. Muhammad Mohiuddin, the Maryland team’s xenotransplantation expert. But, he cautioned, “we don’t want to predict anything. We will take every day as a victory and move forward.”
This kind of single-patient “compassionate use” can provide some information about how the pig organ works but not nearly as much as more formal testing, said Karen Maschke, a research scholar at the Hastings Center who is helping develop ethics and policy recommendations for xenotransplant clinical trials. That FDA allowed this second case “suggests that the agency is not ready to permit a pig heart clinical trial to start,” Mashke added.
The pig heart, provided by Blacksburg, Virginia-based Revivicor, has 10 genetic modifications – knocking out some pig genes and adding some human ones to make it more acceptable to the human immune system.
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