Health
Experts warn bird flu virus changing rapidly in largest ever outbreak

The virus causing record cases of avian influenza in birds across the world is changing rapidly, experts have warned, as calls increase for countries to vaccinate their poultry.
While emphasizing that the risk to humans remains low, the experts who spoke to AFP said that the surging number of bird flu cases in mammals was a cause for concern.
Since first emerging in 1996, the H5N1 avian influenza virus had previously been confined to mostly seasonal outbreaks.
But “something happened” in mid-2021 that made the group of viruses much more infectious, according to Richard Webby, the head of a World Health Organization collaborating center studying influenza in animals.
Since then, outbreaks have lasted all year round, spreading to new areas and leading to mass deaths among wild birds and tens of millions of poultry being culled, AFP reported.
Webby, who is a researcher at St Jude Children’s Research Hospital in the US city of Memphis, told AFP it was “absolutely” the largest outbreak of avian influenza the world had seen.
He led research, published this week in the journal Nature Communications, showing how the virus rapidly evolved as it spread from Europe into North America.
The study said the virus increased in virulence, which means it causes more dangerous disease, when it arrived in North America.
The researchers also infected a ferret with one of the new strains of bird flu.
They found an unexpectedly “huge” amount of the virus in its brain, Webby said, indicating it had caused more serious disease than previous strains.
Emphasizing that the risk in humans was still low, he said that “this virus is not being static, it’s changing”.
“That does increase the potential that even just by chance” the virus could “pick up genetic traits that allow it to be more of a human virus,” he said.
In rare cases, humans have contracted the sometimes deadly virus, usually after coming in close contact with infected birds.
The virus has also been detected in a soaring number of mammals, which Webby described as a “really, really troubling sign”.
Last week Chile said that nearly 9,000 sea lions, penguins, otters, porpoises and dolphins have died from bird flu along its north coast since the start of the year, AFP reported.
Most mammals are believed to have contracted the virus by eating an infected bird.
But Webby said that what “scares us the most” are indications from a Spanish mink farm, or among sea lions off South America, that the virus could be transmitting between mammals.
Ian Brown, virology head at the UK’s Animal and Plant Health Agency, said there has not yet been “clear evidence that this virus is easily sustaining in mammals.”
While the virus is changing to become “more efficient and more effective in birds,” it remains “unadapted to humans,” Brown told AFP.
Avian viruses bind to different receptors on the host cell than human viruses, Webby said.
It would take “two or three minor changes in one protein of the viruses” to become more adapted to humans, he said.
“That is what we’re really looking out for.”
Vaccinating poultry
One way to bring down the number of total bird flu cases, and therefore reduce the risk to humans, would be for countries to vaccinate their poultry, Webby said.
A few nations including China, Egypt and Vietnam have already held vaccination campaigns for poultry.
But many other countries have been reluctant due to import restrictions in some areas, and fears vaccinated birds that nonetheless get infected could slip through the net.
In April, the United States started testing several vaccine candidates for potential use on birds.
France recently said it hopes to start vaccinating poultry as early as autumn this year.
Christine Middlemiss, the UK’s chief veterinary officer, said that vaccinating poultry was not “a silver bullet because the virus changes constantly”.
But traditionally reluctant countries should consider vaccinating poultry more often, Middlemiss told AFP at an event at the UK’s embassy in Paris last week.
World Organisation for Animal Health director general Monique Eloit said that the issue of vaccinating poultry should be “on the table”.
After all, “everyone now knows that a pandemic is not just a fantasy — it could be a reality,” she added.
Health
Saudi Arabia confirms $500 million pledge to Afghanistan, Pakistan polio campaign
The WHO said the funds, initially pledged in April 2024, will be disbursed to help end the wild form of polio in Pakistan and Afghanistan and stop outbreaks of variant polio.

The World Health Organization said Monday Saudi Arabia has reaffirmed its $500 million commitment to the Global Polio Eradication Initiative (GPEI).
The WHO said the funds, initially pledged in April 2024, will be disbursed to help end the wild form of polio in Pakistan and Afghanistan and stop outbreaks of variant polio, Reuters reported.
Wild polio — a naturally occurring form of the viral disease — is endemic in Pakistan and Afghanistan, which together reported 99 cases last year, according to the WHO. Variant polio is caused by the weakening of the oral polio vaccine.
The GPEI hopes to declare an end to the wild virus and the vaccine-derived variant by 2027 and 2029, respectively, compared with a previous deadline of 2026 for both forms.
Health
Chinese researchers find bat virus enters human cells via same pathway as COVID

A newly discovered bat coronavirus uses the same cell-surface protein to gain entry into human cells as the SARS-CoV-2 virus that causes COVID-19, raising the possibility that it could someday spread to humans, Chinese researchers have reported.
The virus does not enter human cells as readily as SARS-CoV-2 does, the Chinese researchers reported in the journal Cell, opens new tab, noting some of its limitations, Reuters reported.
The scientists said that like SARS-CoV-2, the bat virus HKU5-CoV-2 contains a feature known as the furin cleavage site that helps it to enter cells via the ACE2 receptor protein on cell surfaces.
In lab experiments, HKU5-CoV-2 infected human cells with high ACE2 levels in test tubes and in models of human intestines and airways.
In further experiments, the researchers identified monoclonal antibodies and antiviral drugs that target the bat virus.
Bloomberg, which reported on the study earlier on Friday, said the paper identifying the bat virus had moved shares of COVID vaccine makers. Pfizer shares closed up 1.5% on Friday, Moderna climbed 5.3% and Novavax was up about 1% on a down day for the broader market.
Asked about concerns raised by the report of another pandemic resulting from this new virus, Dr. Michael Osterholm, an infectious disease expert at the University of Minnesota, called the reaction to the study “overblown.”
He said there is a lot of immunity in the population to similar SARS viruses compared with 2019, which may reduce the pandemic risk.
The study itself noted that the virus has significantly less binding affinity to human ACE2 than SARS-CoV-2, and other suboptimal factors for human adaptation suggest the “risk of emergence in human populations should not be exaggerated.”
Health
UN warns maternal deaths in Afghanistan may rise after US funding pause
Afghanistan has one of the highest death rates in the world for pregnant women, with a mother dying of preventable pregnancy complications every two hours

A United Nations aid official said on Tuesday that Washington’s funding pause would cut off millions of Afghans from sexual and reproductive health services, and that the continued absence of this support could cause over 1,000 maternal deaths in Afghanistan from 2025 to 2028.
US President Donald Trump last month ordered a 90-day pause in foreign development assistance, pending assessment of efficiencies and consistency with his foreign policy, setting alarm bells ringing among aid groups around the world that depend on US funding.
Trump has also restored US participation in international anti-abortion pacts, cutting off US family planning funds for foreign organisations providing or promoting abortion.
Pio Smith, regional director for Asia and the Pacific at the United Nations sexual and reproductive health agency (UNFPA), said that over nine million people in Afghanistan would lose access to services and over 1.2 million Afghan refugees living in Pakistan would also be affected due to the closure of health facilities.
Afghanistan has one of the highest death rates in the world for pregnant women, with a mother dying of preventable pregnancy complications every two hours, he said.
“What happens when our work is not funded? Women give birth alone, in unsanitary conditions…Newborns die from preventable causes,” he told a Geneva press briefing.
“These are literally the world’s most vulnerable people.”
“If I just take the example of Afghanistan, between 2025 and 2028 we estimate that the absence of US support will result in 1,200 additional maternal deaths and 109,000 additional unintended pregnancies,” he said.
Across the Asia-Pacific region, UNFPA receives about $94 million in US funding, he added.
Riva Eskinazi, director of donor relations at the International Planned Parenthood Federation meanwhile told Reuters it, too, would have to halt family planning and sexual and reproductive health services in West Africa as a result of the pause.
“We can foresee an increase in unintended pregnancies and maternal deaths. There is going to be a problem sending contraceptives to our members. It’s devastating,” she said.
IPPF, a federation of national organisations that advocates for sexual and reproductive health, calculates that it would have to forgo at least $61 million in US funding over four years in 13 countries, most of which are in Africa.
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