Health
U.S. man recovering after ‘breakthrough’ pig-heart transplant
A U.S. man with terminal heart disease was implanted with a genetically modified pig heart in a first-of-its-kind surgery, and three days later the patient is doing well, his doctors reported on Monday.
The surgery, performed by a team at the University of Maryland Medicine, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools, Reuters reported.
If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.
“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.
“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” Griffith added.
According to the report for 57-year-old David Bennett of Maryland, the heart transplant was his last option.
“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said a day before his surgery, according to a statement released by the university.
To move ahead with the experimental surgery, the university obtained an emergency authorization from the U.S. Food and Drug Administration on New Year’s Eve through its compassionate use program.
“The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Muhammad Mohiuddin, who heads the University’s program on xenotransplantation – transplanting animal organs into humans.
About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.
Bennett’s genetically modified pig heart was provided by Revivicor, a regenerative medicine company based in Blacksburg, Virginia. On the morning of the surgery, the transplant team removed the pig’s heart and placed it into a special device to preserve its function until the surgery, read the report.
Pigs have long been a tantalizing source of potential transplants because their organs are so similar to humans. A hog heart at the time of slaughter, for example, is about the size of an adult human heart.
Other organs from pigs being researched for transplantation into humans include kidneys, liver and lungs.
According to Reuters prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.
Scientists have tackled that problem by editing away potentially harmful genes.
In the heart implanted in Bennett, three genes previously linked with organ rejection were “knocked out” of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.
Researchers also deleted a pig gene to prevent excessive growth of the pig heart tissue.
The work was funded in part with a $15.7 million research grant to evaluate Revivicor’s genetically-modified pig hearts in baboon studies.
In addition to the genetic changes to the pig heart, Bennett received an experimental anti-rejection drug made by Kiniksa Pharmaceuticals based in Lexington, Mass.
Health
Four-day polio vaccination campaign begins across Afghanistan
A nationwide polio vaccination campaign got underway across Afghanistan on Monday.
The four-day campaign aims to vaccinate around 12.77 million children under the age of five against polio.
Officials said the campaign is aimed at strengthening protection for children against polio and preventing the spread of the virus.
However, in the southern zone of the country, the polio vaccination campaign will begin one day later, on Tuesday, to ensure better implementation.
According to the information provided, Afghanistan has conducted one nationwide and two sub-national polio vaccination campaigns so far this year. The current campaign is the fourth of the year. In addition, localized campaigns and public awareness programs have also been carried out.
Officials said some environmental samples linked to the polio virus have tested positive. However, the Ministry of Public Health has not so far confirmed any human cases of polio.
According to officials, investigations into suspected cases are ongoing, and information on confirmed human cases will be shared once the assessments are completed and sufficient evidence is available.
Health
Afghanistan faces cancer treatment crisis
Spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country.
The Afghanistan Cancer Foundation has raised concern over the rising number of cancer cases across the country, saying at least 1.5 million people are currently suffering from the disease.
According to figures released on Saturday, September 11, about 50,000 new cases are recorded annually. The figures are based on data from the Ministry of Public Health and international organizations.
Shafiq Shinwari, head of the Afghan Cancer Foundation, said in a recent interview that breast and uterine cancers are among the most common cancers in women, while lung, stomach, prostate and colon cancers are widespread among men.
He said cancer is the second-leading cause of death in Afghanistan after heart disease.
Cancer specialist Dr. Rahim Gul Darwish identified smoking and tobacco use, poor hygiene and unhealthy diets as major factors contributing to the spread of the disease.
Meanwhile, Sharafat Zaman Amarkhail, spokesperson for the Ministry of Public Health, said dozens of cancer treatment centers are operating across the country. However, he acknowledged serious shortages of modern equipment and facilities needed to provide comprehensive treatment.
The situation has been further aggravated by the departure of hundreds of medical specialists and healthcare workers since the Islamic Emirate returned to power, according to reports.
Afghan patients have also faced growing difficulties accessing treatment abroad. Many previously travelled to Pakistan for cancer care, but border closures and restrictions on Pakistani visas have made access more difficult.
Doctors say cancer patients require continuous treatment and regular specialist care, warning that shortages of facilities and restrictions on cross-border travel are increasing the risks for patients.
Health
Genetically modified pig kidney keeps man alive for record nine months
A genetically modified pig kidney has kept a 66-year-old man with end-stage kidney disease alive without dialysis for a record nine months, marking the first time a pig kidney has successfully served as a temporary “bridge” to a human kidney transplant.
Tim Andrews, from New Hampshire, was suffering from severe kidney failure caused by type 2 diabetes. Doctors said he had only a 9% chance of receiving a human kidney within five years, while facing a more than 40% risk of dying or being removed from the transplant waiting list.
Surgeons at Mass General Brigham in Massachusetts transplanted a kidney from a genetically modified Yucatan miniature pig named Wilma into Andrews in January 2025. The kidney functioned for 271 days, allowing him to remain free of dialysis before it began to fail.
After the pig kidney was removed, Andrews spent several months back on dialysis before receiving a kidney from a deceased human donor. The human kidney was functioning well after six months of follow-up, according to findings published in the medical journal The Lancet.
The transplant represents the longest dialysis-free survival recorded following a pig kidney xenotransplant in a living person. It is also the first documented case in which a patient successfully moved from a pig kidney transplant to a human kidney transplant.
Before the procedure, Wilma’s genome underwent 69 genetic modifications. Some changes were intended to reduce the risk of viruses being transmitted to humans, while others were designed to make the pig kidney more compatible with the human immune system and reduce the risk of rejection.
Andrews described the procedure as a “miracle”, saying it allowed him to return to everyday activities. He said he was able to cook, vacuum and take long walks with his dog.
The development could offer a potential solution to the severe shortage of human organs available for transplantation. Kidney transplantation provides the best survival prospects and quality of life for patients with end-stage kidney disease, but the global demand for donor kidneys far exceeds the supply.
Dr Leonardo Riella of Mass General Brigham said the shortage of organs remains “the greatest crisis” in transplantation. He said genetically modified animal organs could initially be used to help patients avoid dialysis while they wait for a human donor kidney and could eventually become a long-term treatment option if their safety and durability are established.
The pig kidney began showing damage to its blood vessels after about six months, eventually leading to organ failure and its removal nine months after transplantation.
Doctors found no new antibodies against human tissue following the procedure, suggesting the pig kidney did not make Andrews’ subsequent human transplant more difficult. No pig viruses or other pig pathogens were detected at any point.
The researchers cautioned that the result is based on a single patient with no comparison group. They said the outcome also depended on careful patient selection and intensive specialist care that may not be available in all settings.
Further clinical trials will be needed to determine whether genetically modified pig kidneys can safely and reliably be used as a bridge for other patients facing long waits for human organs.
The researchers said the case nevertheless provides new evidence that pig kidney transplantation could help address the global organ shortage and potentially offer patients a way to remain off dialysis while waiting for a human kidney.
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