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Scientists use stem cells to create synthetic mouse embryos

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Scientists have created “synthetic” mouse embryos from stem cells without a dad’s sperm or a mom’s egg or womb.

The lab-created embryos mirror a natural mouse embryo up to 8 ½ days after fertilization, containing the same structures, including one like a beating heart.

In the near term, researchers hope to use these so-called embryoids to better understand early stages of development and study mechanisms behind disease without the need for as many lab animals. The feat could also lay the foundation for creating synthetic human embryos for research in the future, AP reported.

“We are undoubtedly facing a new technological revolution, still very inefficient … but with enormous potential,” said Lluís Montoliu, a research professor at the National Biotechnology Centre in Spain who is not part of the research. “It is reminiscent of such spectacular scientific advances as the birth of Dolly the sheep” and others.

A study published Thursday in the journal Nature, by Magdalena Zernicka-Goetz at the California Institute of Technology and her colleagues, was the latest to describe the synthetic mouse embryos. A similar study, by Jacob Hanna at the Weizmann Institute of Science in Israel and his colleagues, was published earlier this month in the journal Cell. Hanna was also a coauthor on the Nature paper.

Zernicka-Goetz, an expert in stem cell biology, said one reason to study the early stages of development is to get more insight into why the majority of human pregnancies are lost at an early stage and embryos created for in vitro fertilization fail to implant and develop in up to 70% of cases. Studying natural development is difficult for many reasons, she said, including the fact that very few human embryos are donated for research and scientists face ethical constraints.

Building embryo models is an alternative way to study these issues.

To create the synthetic embryos, or “embryoids,” described in the Nature paper, scientists combined embryonic stem cells and two other types of stem cells – all from mice. They did this in the lab, using a particular type of dish that allowed the three types of cells to come together. While the embryoids they created weren’t all perfect, Zernicka-Goetz said, the best ones were “indistinguishable” from natural mouse embryos. Besides the heart-like structure, they also develop head-like structures.

”This is really the first model that allows you to study brain development in the context of the whole developing mouse embryo,” she said.

The roots of this work go back decades, and both Zernicka-Goetz and Hanna said their groups were working on this line of research for many years. Zernicka-Goetz said her group submitted its study to Nature in November.

Scientists said next steps include trying to coax the synthetic mouse embryos to develop past 8 ½ days – with the eventual goal of getting them to term, which is 20 days for a mouse.

“In the future, similar experiments will be done with human cells and that, at some point, will yield similar results,” he said. “This should encourage considerations of the ethics and societal impact of these experiments before they happen.”

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Trump grants TikTok another 90-day extension to find non-Chinese buyer

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President Donald Trump announced he will sign an executive order this week extending the deadline for TikTok to divest from its Chinese parent company, ByteDance, by another 90 days—pushing the deadline into mid-September.

This extension marks the third reprieve since the original ban deadline passed on January 19 under a US protection Act.

Trump justified the move by emphasizing ongoing efforts to finalize a sale while ensuring U.S. user data protection.

Critics argue Trump’s repeated extensions may exceed legal authority, citing that the law permits only one such extension .

Republican and Democratic lawmakers alike have voiced concerns, warning that the law’s requirements haven’t been met and further delays could undermine U.S. national security.

A near-final deal led by Oracle was disrupted after new U.S. tariffs triggered Beijing’s refusal to approve the transaction.

With China’s approval still pending and legal limits tested, analysts express skepticism over whether further extensions are viable or sustainable.

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World’s first intercontinental robotic prostate surgery connects Rome to Beijing

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In a medical breakthrough, a Chinese surgical team has completed the world’s first intercontinental robotic prostatectomy, successfully connecting a surgeon in Rome with a patient undergoing surgery in Beijing.

The operation, hailed as a major leap forward for telesurgery, showcased how advanced technology can eliminate geographical barriers in delivering highly specialized medical care.

Dr. Zhang Xu, head of urology at the PLA General Hospital in Beijing, led the procedure entirely from Italy, remotely controlling robotic surgical instruments located more than 8,000 kilometers away in China.

Using a cutting-edge robotic system and powered by ultra-fast 5G and high-speed fiber-optic networks, the surgery was executed with real-time precision.

The low-latency digital connection was essential to ensure accurate, responsive control — a technical challenge that was once considered a major hurdle to remote surgery.

A standby surgical team was present in Beijing to assist in case of emergencies, but the entire procedure was directed by Zhang from Europe, marking an unprecedented demonstration of international surgical collaboration.

This landmark operation signals a promising future for telemedicine, especially for rural and underserved regions. It illustrates a world in which expert surgeons can operate from thousands of miles away, bringing top-tier care to places that lack access to advanced medical facilities.

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Japan’s ispace fails again: Resilience lander crashes on moon

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Japanese company ispace said its uncrewed moon lander likely crashed onto the lunar surface during its touchdown attempt on Friday, marking another failure two years after an unsuccessful inaugural mission.

Tokyo-based ispace had hoped to join U.S. firms Intuitive Machines and Firefly Aerospace in making successful commercial moon landings amid a global race that includes state-run lunar missions from China and India, Reuters reported.

Although the failure means another multi-year pause in Japan’s commercial access to the moon, the country remains committed to the U.S.-led Artemis program and a wide range of Japanese companies are studying lunar exploration as a business frontier.

Resilience, ispace’s second lunar lander, had problems measuring its distance to the surface and could not slow its descent fast enough, the company said, adding it has not been able to communicate with Resilience after a likely hard landing.

“Truly diverse scenarios were possible, including issues with the propulsion system, software or hardware, especially with sensors,” ispace Chief Technology Officer Ryo Ujiie told a press conference.

A room of more than 500 ispace employees, shareholders, sponsors and government officials abruptly grew silent when flight data was lost less than two minutes before the scheduled touchdown time during a public viewing event at mission partner Sumitomo Mitsui Banking Corp in the wee hours in Tokyo.

Shares of ispace were untraded, overwhelmed by sell orders, and looked set to close at the daily limit-low, which would mark a 29% fall. As of the close of Thursday, ispace had a market capitalisation of more than 110 billion yen ($766 million).

“We’re not facing any immediate financial deterioration or distress because of the event,” CFO Jumpei Nozaki said in the press conference, citing recurring investor support.

In 2023, ispace’s first lander crashed into the moon’s surface due to inaccurate recognition of its altitude. Software remedies have been implemented, while the hardware design was mostly unchanged in Resilience.

$16 MILLION PAYLOAD

Resilience was carrying a four-wheeled rover built by ispace’s Luxembourg subsidiary and five external payloads worth a total of $16 million, including scientific instruments from Japanese firms and a Taiwanese university.

The lander had targeted Mare Frigoris, a basaltic plain about 900 km (560 miles) from the moon’s north pole.

If the landing had been successful, the 2.3-metre-high lander and the rover would have begun 14 days of planned exploration activities, including capturing of regolith, the moon’s fine-grained surface material, on a contract with U.S. space agency NASA.

Resilience in January shared a SpaceX rocket launch with Firefly’s Blue Ghost lander, which took a faster trajectory to the moon and touched down successfully in March.

Intuitive Machines, which last year marked the world’s first commercial lunar touchdown, also landed its second Athena lander in March, although in a toppled position just as with its first mission.

Japan last year became the world’s fifth country to achieve a soft lunar landing after the former Soviet Union, the United States, China and India, when the national Japan Aerospace Exploration Agency achieved the touchdown of its SLIM lander.

The government last year signed an agreement with NASA to include Japanese astronauts in Artemis lunar missions and has supported private companies’ research projects for future lunar development, assuming ispace’s transportation capabilities.

“Expectations for ispace have not faded,” Japanese Prime Minister Shigeru Ishiba said in an X post.

Although ispace will likely remain Japan’s most advanced lunar transportation company, some Japanese firms may start to consider transport options from foreign entities to test their lunar exploration visions, said Ritsumeikan University professor Kazuto Saiki, who was involved in the SLIM mission.

For its third mission in 2027, ispace’s U.S. unit is building a bigger lander as part of NASA’s Commercial Lunar Payload Services for the Artemis program. The company projects six more missions in the U.S. and Japan through 2029.

“NASA increasingly needs private companies to improve cost efficiency for key missions with limited budgets,” ispace CEO Takeshi Hakamada said, referring to U.S. President Donald Trump’s proposed budget cuts.

“To meet NASA’s expectations, we’ll support our U.S. subsidiary to keep up with development and play a role.”

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