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U.S. man recovering after ‘breakthrough’ pig-heart transplant

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A U.S. man with terminal heart disease was implanted with a genetically modified pig heart in a first-of-its-kind surgery, and three days later the patient is doing well, his doctors reported on Monday.

The surgery, performed by a team at the University of Maryland Medicine, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools, Reuters reported.

If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” Griffith added.

According to the report for 57-year-old David Bennett of Maryland, the heart transplant was his last option.

“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said a day before his surgery, according to a statement released by the university.

To move ahead with the experimental surgery, the university obtained an emergency authorization from the U.S. Food and Drug Administration on New Year’s Eve through its compassionate use program.

“The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Muhammad Mohiuddin, who heads the University’s program on xenotransplantation – transplanting animal organs into humans.

About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.

Bennett’s genetically modified pig heart was provided by Revivicor, a regenerative medicine company based in Blacksburg, Virginia. On the morning of the surgery, the transplant team removed the pig’s heart and placed it into a special device to preserve its function until the surgery, read the report.

Pigs have long been a tantalizing source of potential transplants because their organs are so similar to humans. A hog heart at the time of slaughter, for example, is about the size of an adult human heart.

Other organs from pigs being researched for transplantation into humans include kidneys, liver and lungs.

According to Reuters prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.

Scientists have tackled that problem by editing away potentially harmful genes.

In the heart implanted in Bennett, three genes previously linked with organ rejection were “knocked out” of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.

Researchers also deleted a pig gene to prevent excessive growth of the pig heart tissue.

The work was funded in part with a $15.7 million research grant to evaluate Revivicor’s genetically-modified pig hearts in baboon studies.

In addition to the genetic changes to the pig heart, Bennett received an experimental anti-rejection drug made by Kiniksa Pharmaceuticals based in Lexington, Mass.

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Afghan Health Minister hails India visit as new chapter in bilateral ties

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Afghanistan’s Minister of Public Health, Noor Jalal Jalali, has described his recent visit to India as an important new chapter in strengthening health cooperation between Kabul and New Delhi.

Speaking at a press conference in Kabul on Tuesday, Jalali said the trip focused on expanding bilateral health collaboration and addressing key challenges facing Afghanistan’s healthcare system. He outlined the main objectives of the visit as preventing potential medicine shortages, standardizing traditional medicine, importing high-quality and affordable medicines, building the capacity of health workers through training programs, facilitating medical treatment for Afghan patients in India, and developing professional expertise in traditional medicine.

Jalali said India and relevant institutions made several concrete commitments during the visit. These include the provision of vaccines worth $5 million, a radiotherapy machine for cancer treatment valued at $3 million, five tons of cancer medicines worth $1 million, a CT scan machine valued at $300,000, and support for the construction of a hospital and a specialized thalassemia treatment center valued at $500,000.

According to a statement from the Ministry of Public Health, the visit also resulted in agreements on capacity-building programs for specialists and healthcare workers, the donation of 70,000 medical ampoules by an Afghan investor, plans to establish a research center and an institute of traditional medicine in Kabul, the transfer of high-quality medicines to Afghanistan, meeting market needs, and increased investment in the health sector.

The ministry said these outcomes represent significant progress in enhancing healthcare services and long-term cooperation between Afghanistan and India.

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Afghan health minister hails India’s support, calls medical visas vital for patients

Jalali said India is planning to build a 30-bed hospital in Kabul’s Bagrami district, which is expected to include an oncology center, a trauma unit, and maternal and child healthcare clinics.

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Afghanistan’s Minister of Public Health, Noor Jalal Jalali, has praised India’s long-standing support for Afghanistan’s healthcare sector, describing Indian medical visas as a “vital humanitarian channel” for Afghan patients.

In an interview with an Indian television network, during his official visit to New Delhi, Jalali said Afghans have long relied on India for medical treatment, noting that the facilitation of medical visas has enabled thousands of patients to access advanced healthcare services in recent years.

He welcomed India’s contributions to Afghanistan’s health infrastructure, highlighting the Indira Gandhi Institute of Child Health in Kabul as one of the country’s most important pediatric hospitals.

India has supported the facility through the establishment of a thalassemia center, a modern diagnostic unit, upgrades to heating systems, and plans to provide a CT scan machine.

Jalali said India is also planning to build a 30-bed hospital in Kabul’s Bagrami district, which is expected to include an oncology center, a trauma unit, and maternal and child healthcare clinics.

He added that India has fitted around 75 Afghan patients with prosthetic limbs under the Jaipur Foot program and donated 20 ambulances.

During talks with India’s Minister of Health and Family Welfare, Jalali called for expanded cooperation in medical equipment, pharmaceutical regulation, training of healthcare workers, and the supply of essential medicines, particularly cancer drugs. He said India has pledged to provide these medicines on an urgent basis.

The Afghan health minister stressed the importance of capacity building, including training Afghan doctors in India and deploying Indian medical teams to Afghanistan.

He also said agreements have been reached to cooperate in traditional medicine, including Ayurveda and Unani practices, with plans to establish a Traditional Medicine Institute and Research Center in Afghanistan.

Jalali noted that Afghanistan has diversified its pharmaceutical import routes to ensure a steady supply of medicines and address concerns over counterfeit and substandard drugs through stronger regulation.

He described Afghanistan–India relations as people-centric and rooted in humanitarian values, expressing hope that cooperation in healthcare, pharmaceuticals, and medical infrastructure will continue to deepen.

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Afghan health officials visit Indian medical institute to expand ties

India has historically been a key partner in Afghanistan’s health and education sectors, providing training, medical support and institutional cooperation.

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During an official visit to India, a technical delegation from Afghanistan’s Ministry of Public Health visited the Hamdard Institute of Medical Sciences and Research (HIMSR) in New Delhi, as part of efforts to strengthen cooperation in the health sector, particularly in the field of traditional medicine.

Officials and senior professors at HIMSR welcomed the Afghan team and provided detailed briefings on the institution’s academic programmes, research activities and medical services.

Discussions focused on opportunities for closer collaboration in traditional and integrative medicine, an area where Hamdard has long-standing expertise and international recognition.

HIMSR’s leadership expressed readiness to work with Afghan health authorities on joint research initiatives, quality testing and standardisation of traditional medicines through Hamdard’s laboratories, as well as knowledge-sharing programmes. The institution also pledged to offer scholarships and specialised training opportunities for Afghan doctors and medical professionals.

The visit comes as Afghanistan seeks to rebuild and strengthen its public health system amid ongoing economic and humanitarian challenges, with an emphasis on cost-effective and culturally accepted healthcare approaches such as traditional medicine.

India has historically been a key partner in Afghanistan’s health and education sectors, providing training, medical support and institutional cooperation.

Both sides said enhanced collaboration would contribute to improving public health outcomes, standardising traditional medicine practices, and expanding scientific and medical institutions in Afghanistan.

They reaffirmed their commitment to developing the partnership in a sustainable manner, aimed at long-term capacity building and mutual benefit.

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