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U.S. man recovering after ‘breakthrough’ pig-heart transplant

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A U.S. man with terminal heart disease was implanted with a genetically modified pig heart in a first-of-its-kind surgery, and three days later the patient is doing well, his doctors reported on Monday.

The surgery, performed by a team at the University of Maryland Medicine, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools, Reuters reported.

If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” Griffith added.

According to the report for 57-year-old David Bennett of Maryland, the heart transplant was his last option.

“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said a day before his surgery, according to a statement released by the university.

To move ahead with the experimental surgery, the university obtained an emergency authorization from the U.S. Food and Drug Administration on New Year’s Eve through its compassionate use program.

“The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Muhammad Mohiuddin, who heads the University’s program on xenotransplantation – transplanting animal organs into humans.

About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.

Bennett’s genetically modified pig heart was provided by Revivicor, a regenerative medicine company based in Blacksburg, Virginia. On the morning of the surgery, the transplant team removed the pig’s heart and placed it into a special device to preserve its function until the surgery, read the report.

Pigs have long been a tantalizing source of potential transplants because their organs are so similar to humans. A hog heart at the time of slaughter, for example, is about the size of an adult human heart.

Other organs from pigs being researched for transplantation into humans include kidneys, liver and lungs.

According to Reuters prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.

Scientists have tackled that problem by editing away potentially harmful genes.

In the heart implanted in Bennett, three genes previously linked with organ rejection were “knocked out” of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.

Researchers also deleted a pig gene to prevent excessive growth of the pig heart tissue.

The work was funded in part with a $15.7 million research grant to evaluate Revivicor’s genetically-modified pig hearts in baboon studies.

In addition to the genetic changes to the pig heart, Bennett received an experimental anti-rejection drug made by Kiniksa Pharmaceuticals based in Lexington, Mass.

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Afghan delegation heads to Turkey for medicine talks

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Naemullah Ayoubi, Director General of Drug and Health Products Regulation at Afghanistan’s Ministry of Public Health, has departed for Turkey on an official visit accompanied by a technical delegation.

The Ministry of Public Health said the delegation will hold meetings with officials from Turkey’s pharmaceutical regulatory authority and discuss a number of key issues related to the regulation of medicines and health products.

The delegation is also scheduled to visit several pharmaceutical manufacturing factories in Turkey.

According to the ministry, the visit aims to strengthen coordination between the two countries in the production and import of medicines, in order to ensure the availability of high-quality and affordable pharmaceuticals for people in Afghanistan in both the short and long term.

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Afghanistan opens first national cancer diagnosis and treatment hospital

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The Ministry of Public Health announced on Thursday that Afghanistan has inaugurated its first national hospital dedicated to the diagnosis and treatment of cancer, marking a major step forward in the country’s healthcare services.

The facility, named the National Cancer Diagnostic and Therapeutic Hospital, has officially begun operations and will provide specialized care for cancer patients across the country.

Speaking at the inauguration ceremony, Public Health Minister Noor Jalal Jalali said the 200-bed hospital aims to offer hope and improved treatment options for patients suffering from cancer.

“Fortunately, we are jointly opening a 200-bed hospital for cancer patients, and we hope that this hospital will become a source of hope and healing for those in need,” Jalali said.

The minister added that specialized training programs will soon be launched at the hospital to educate and train domestic medical specialists. He noted that reforms have already been implemented to improve facilities and ensure better healthcare services.

Jalali also emphasized international cooperation in the project, saying that radiotherapy services will be introduced at the hospital with support from India. According to the ministry, India has so far provided $1 million in assistance, including 10 tons of medicines and medical equipment, to support cancer treatment in Afghanistan.

The opening of the hospital is expected to reduce the need for Afghan patients to seek costly cancer treatment abroad and improve access to specialized care inside the country.

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Pakistan becomes latest Asian country to introduce checks for deadly Nipah virus

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Authorities in Pakistan have ordered enhanced screening of people entering the country for signs of infections of the deadly Nipah virus after India confirmed two cases, adding to the number of Asian countries stepping up controls.

Thailand, Singapore, Hong Kong, Malaysia, Indonesia and Vietnam have also tightened screening at airports, Reuters reported.

The Nipah virus can cause fever and brain inflammation and has a high mortality rate. There is also no vaccine. But transmission from person to person is not easy and typically requires prolonged contact with an infected individual.

“It has become imperative to strengthen preventative and surveillance measures at Pakistan’s borders,” the Border Health Services department said in a statement.

“All travelers shall undergo thermal screening and clinical assessment at the Point of Entry,” which includes seaports, land borders and airports, the department added.

The agency said travellers would need to provide transit history for the preceding 21-day period to check whether they had been through “Nipah-affected or high-risk regions”.

There are no direct flights between Pakistan and India and travel between the two countries is extremely limited, particularly since their worst fighting in decades in May last year.

In Hanoi, the Vietnamese capital’s health department on Wednesday also ordered the screening of incoming passengers at Noi Bai airport, particularly those arriving from India and the eastern state of West Bengal, where the two health workers were confirmed to have the virus in late December.

Passengers will be checked with body temperature scanners to detect suspected cases. “This allows for timely isolation, epidemiological investigation,” the department said in a statement.

That follows measures by authorities in Ho Chi Minh City, Vietnam’s largest city, who said they had tightened health controls at international border crossings.

India’s health ministry said this week that authorities have identified and traced 196 contacts linked to the two cases with none showing symptoms and all testing negative for the virus.

Nipah is a rare viral infection that spreads largely from infected animals, mainly fruit bats, to humans. It can be asymptomatic but it is often very dangerous, with a case fatality rate of 40% to 75%, depending on the local healthcare system’s capacity for detection and management, according to the World Health Organization.

The virus was first identified just over 25 years ago during an outbreak among pig farmers in Malaysia and Singapore, although scientists believe it has circulated in flying foxes, or fruit bats, for thousands of years.

The WHO classifies Nipah as a priority pathogen. India regularly reports sporadic infections, particularly in the southern state of Kerala, regarded as one of the world’s highest-risk regions for Nipah.

As of December 2025, there have been 750 confirmed Nipah infections globally, with 415 deaths, according to the Coalition for Epidemic Preparedness Innovations, which is funding a vaccine trial to help stop Nipah.

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