Iran told Pakistan’s army chief on Tuesday that there would be no talks with Washington until Tehran’s ​demands were met, Iranian media reported, underscoring its hardening stance despite ‌mediation efforts by key interlocutor Pakistan.

President Masoud Pezeshkian discussed mediation efforts and regional developments with Field Marshal Asim Munir in Tehran, according to Nournews.

Pakistan is a key intermediary between ​the United States and Iran. Earlier mediation efforts helped produce an interim ​peace agreement in June, but the Islamabad Memorandum quickly unravelled ⁠as fighting between Iran and the US resumed weeks after.

Munir also met ​Iranian parliament speaker Mohammad Baqer Qalibaf, who said Washington could not regain Tehran’s ​trust until it fulfilled seven conditions Iran set last month for reopening the Strait of Hormuz, according to an Iranian readout of the meeting.

The demands include ending a US ​blockade on its ports, the lifting of sanctions on its oil exports ​as well as ending hostilities on all regional fronts.

Iran’s security chief, Mohsen Rezaei, ‌delivered a similar ⁠message during a separate meeting with Munir, saying there would be no talks with Washington until Tehran’s demands were met, according to Iranian media.

Rezaei also said all enriched nuclear materials would remain in Iran, reiterating Supreme Leader ​Ayatollah Mojtaba Khamenei’s position ​that near-weapons-grade uranium ⁠should not be shipped abroad.

US Vice President JD Vance said earlier this month that Iran must make a “meaningful” reduction ​in its uranium enrichment capacity to satisfy US demands and ​end ⁠the countries’ eight-month-old war.

Israel, the United States and other Western states have long accused Iran of seeking nuclear weapons, including pointing to its move to ⁠enrich uranium ​to 60%, far higher than needed for ​civilian uses and closer to the 90% needed for a weapon.

Iran denies seeking nuclear weapons.

While the Iran war smolders, Saudi Arabia fights the Houthis and a new rift opens in US-Ukraine relations, Secretary of State Marco Rubio travels on Sunday to ​Uzbekistan, a nation far removed from the biggest US foreign policy challenges.

The top US diplomat is scheduled to land in Samarkand on Sunday to meet with ‌leaders from the C5+1, a grouping that brings together the United States and the Muslim-majority post-Soviet states of Uzbekistan, Kazakhstan, Kyrgyzstan, Tajikistan and Turkmenistan.

US officials have portrayed resource-rich Central Asia — the region between China, Russia and Iran — as worthy of more attention than it received from US President Donald Trump’s predecessors.

Trump hosted C5 leaders at the White House last November, when Kazakhstan agreed to join the Abraham Accords, a series of agreements under ​which Muslim-majority countries have normalized or deepened relations with Israel. Separately, Trump met with Uzbek President Shavkat Mirziyoyev at the United Nations General Assembly last September.

Regional politics aside, ​the trip fits an emerging pattern in which Rubio often visits regions not at the center of the news cycle, while leaving some more ⁠fraught foreign-policy portfolios to other Trump aides, including special envoys Steve Witkoff and Jared Kushner and Vice President JD Vance.

For instance, Rubio has not visited Kyiv or Moscow since becoming ​secretary of state. He was not present for talks between US and Ukrainian officials in Florida earlier this month, when US officials pressed Ukraine to stop hitting Russian refineries. Vance, not Rubio, ​represented the US in Pakistan during peace talks with Iran in April.

Rubio’s previous foreign trip, in early October, took him to Greece, Portugal and Iceland.

Trump administration officials have typically rejected any suggestion that cabinet-level officials should focus their travels on geopolitical capitals and hot spots.

Deputy Secretary of State Christopher Landau, for instance, said on X last week that the idea only certain destinations were worthy of visits from secretaries of state “perfectly encapsulates ​the decadence and degeneracy of the contemporary US foreign policy establishment.”

US-RUSSIA RELATIONS LOOM

One Central Asian diplomat, speaking on the condition of anonymity, said officials in the region are wondering to what ​extent the US will continue targeting Russian sanctions evasion. All C5 states, while drawing closer to the US, have deep historical ties with Moscow, and the region has facilitated Russian imports and exports that violate ‌US and ⁠European Union sanctions, Western officials say.

In the past, the US has pushed regional states to clamp down on those illicit flows.

But Trump struck a deal with Moscow this month to import Russian diesel, a move to lower domestic fuel prices before the congressional midterm elections. On Friday, Trump waived all provisions of legislation that would have allowed him to slap massive tariffs on some nations that buy significant amounts of Russian crude or otherwise help Moscow evade sanctions. Among the nations that could have been affected, experts have said, are India and Kazakhstan.

India, which Rubio will visit after ​Uzbekistan, remains the world’s No. 2 Russian crude ​importer after China, despite Trump saying in ⁠February that India had agreed to stop buying oil from Russia.

Additional questions hang over a potential trade deal with India and an expansion of the Abraham Accords in Central Asia.

A US official, speaking on the condition of anonymity, described the trade deal on Friday as “pretty much done,” ​raising the possibility that an agreement could be announced during the Rubio trip.

Separately, the US has talked to additional Central Asian nations about ​joining the Abraham Accords, Reuters ⁠reported last year, conversations that could in theory continue in Samarkand.

More than 200 business executives will accompany Rubio to Uzbekistan, the State Department said. The Central Asian diplomat said the Trump administration has focused its commercial efforts on expanding access to the area’s rare earth mineral resources.

The trip to Uzbekistan was largely organized by Sergio Gor, the US ambassador to India, the Central Asian diplomat said. Gor, ⁠who was ​born in Uzbekistan and is a friend of Rubio, also serves as the US special envoy for South and ​Central Asian affairs.

After Uzbekistan, Rubio will visit the Indian cities of Mumbai and Jamnagar to meet with business leaders, including Reliance Industries Chairman Mukesh Ambani, who earned the Trump administration’s favor earlier in the year by backing a new ​refinery in Texas. Rubio most recently visited India five months ago.

The trip is due to wrap up on Thursday.

US President Donald Trump has said Washington may launch further strikes against Iran’s underground nuclear facilities, including the site known as Pickaxe Mountain, as he seeks to prevent Tehran from developing a nuclear weapon, Reuters reported.

In an interview with Newsmax on Thursday night, Trump said the United States was determined to ensure Iran never obtains a nuclear weapon, arguing that such a development would pose a serious threat.

“Their nuclear is buried under millions of tons of mountain. Now we’re looking at Pickaxe Mountain. We may have to go there. We’ll take a shot at that one. We’ll knock it out fast,” Trump said.

Pickaxe Mountain is a heavily fortified underground facility linked to Iran’s nuclear programme, located near one of the country’s major nuclear sites.

Trump also ruled out the use of nuclear weapons in the conflict, saying conventional military capabilities would be sufficient to achieve US objectives.

“I wouldn’t use nuclear. We don’t have to,” he said.

The US president reiterated that he was not considering deploying American ground troops into Iran, signalling that Washington’s military approach would continue to rely on other forms of military action.

Trump did not confirm whether he had authorised the use of the GBU-43/B Massive Ordnance Air Blast (MOAB) bomb, commonly known as the “Mother of All Bombs,” against Iranian energy infrastructure or nuclear facilities. He stressed that the weapon was not nuclear, read the report.

The remarks come amid escalating tensions between Washington and Tehran following US-Israeli strikes on Iran that began in February, with Iran’s nuclear programme remaining a central issue in the conflict.

The potential targeting of deeply buried nuclear facilities could further intensify the conflict and raise concerns about the broader regional security situation.